ArticlePlant physiology2002
Genome-wide identification of nodule-specific transcripts in the model legume Medicago truncatula.
Article in Plant physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
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Who cites it
82 citing papers in PubMed, 233 citations in OpenAlex.
- Loss of Nod25 function does not affect nitrogen-fixing symbiosis in Medicago truncatula.Plant molecular biology · 2026Article
- Transcriptome and metabolome analyses reveal regulatory networks associated with nutrition synthesis in sorghum seeds.Communications biology · 2024Article
- Exploring the role of symbiotic modifier peptidases in the legume - rhizobium symbiosis.Archives of microbiology · 2024Review
- Genome-wide association study reveals genomic loci influencing agronomic traits in Ethiopian sorghum (Molecular breeding : new strategies in plant improvement · 2023Article
- Insight into the control of nodule immunity and senescence during Medicago truncatula symbiosis.Plant physiology · 2023Article
- Genes Associated with Biological Nitrogen Fixation Efficiency Identified Using RNA Sequencing in Red Clover (Life (Basel, Switzerland) · 2022Article
- Time Series Transcriptome Analysis inFrontiers in plant science · 2022Article
- Comparative transcriptome analysis during seeds development between two soybean cultivars.PeerJ · 2021Article
- Transcription Factor bHLH2 RepressesPlant physiology · 2019Article
- Characterization and Rapid Gene-Mapping of Leaf Lesion Mimic Phenotype ofInternational journal of molecular sciences · 2019Article
- Sulfate is transported at significant rates through the symbiosome membrane and is crucial for nitrogenase biosynthesis.Plant, cell & environment · 2019Article
- Article
- Nodulation and Delayed Nodule Senescence: Strategies of Two Bradyrhizobium Japonicum Isolates with High Capacity to Fix Nitrogen.Current microbiology · 2018Article
- Genome-wide identification, classification, and expression of phytocyanins in Populus trichocarpa.Planta · 2018Article
- MtCAS31 Aids Symbiotic Nitrogen Fixation by Protecting the Leghemoglobin MtLb120-1 Under Drought Stress inFrontiers in plant science · 2018Article
- Impact of Plant Peptides on Symbiotic Nodule Development and Functioning.Frontiers in plant science · 2018Review
- Integration of Lupinus angustifolius L. (narrow-leafed lupin) genome maps and comparative mapping within legumes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2016Article
- Loss of the nodule-specific cysteine rich peptide, NCR169, abolishes symbiotic nitrogen fixation in the Medicago truncatula dnf7 mutant.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- An antimicrobial peptide essential for bacterial survival in the nitrogen-fixing symbiosis.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Nitrogen-Fixing Nodules Are an Important Source of Reduced Sulfur, Which Triggers Global Changes in Sulfur Metabolism in Lotus japonicus.The Plant cell · 2015Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Medicago truncatula expressed sequence tag (EST) database (Gene Index) contains over 140,000 sequences from 30 cDNA libraries. This resource offers the possibility of identifying previously uncharacterized genes and assessing the frequency and tissue specificity of their expression in silico. Because M. truncatula forms symbiotic root nodules, unlike Arabidopsis, this is a particularly important approach in investigating genes specific to nodule development and function in legumes. Our analyses have revealed 340 putative gene products, or tentative consensus sequences (TCs), expressed solely in root nodules. These TCs were represented by two to 379 ESTs. Of these TCs, 3% appear to encode novel proteins, 57% encode proteins with a weak similarity to the GenBank accessions, and 40% encode proteins with strong similarity to the known proteins. Nodule-specific TCs were grouped into nine categories based on the predicted function of their protein products. Besides previously characterized nodulins, other examples of highly abundant nodule-specific transcripts include plantacyanin, agglutinin, embryo-specific protein, and purine permease. Six nodule-specific TCs encode calmodulin-like proteins that possess a unique cleavable transit sequence potentially targeting the protein into the peribacteroid space. Surprisingly, 114 nodule-specific TCs encode small Cys cluster proteins with a cleavable transit peptide. To determine the validity of the in silico analysis, expression of 91 putative nodule-specific TCs was analyzed by macroarray and RNA-blot hybridizations. Nodule-enhanced expression was confirmed experimentally for the TCs composed of five or more ESTs, whereas the results for those TCs containing fewer ESTs were variable.
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