ArticleProceedings of the National Academy of Sciences of the United States of America2002
Soluble peptide-MHC monomers cause activation of CD8+ T cells through transfer of the peptide to T cell MHC molecules.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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Who cites it
34 citing papers in PubMed, 74 citations in OpenAlex.
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- The transcription factor ZEB2 mediates the antitumor efficacy of tumor-infiltrating lymphocytes in non-small cell lung cancer.Cell death & disease · 2025Article
- Mechanical control of antigen detection and discrimination by T and B cell receptors.Biophysical journal · 2024Review
- A dynamic biomimetic model of the membrane-bound CD4-CD3-TCR complex during pMHC disengagement.Biophysical journal · 2023Article
- Increased soluble HLA in COVID-19 present a disease-related, diverse immunopeptidome associated with T cell immunity.iScience · 2022Article
- Rapid cloning of antigen-specific T-cell receptors by leveraging the cis activation of T cells.Nature biomedical engineering · 2022Article
- DNA origami patterning of synthetic T cell receptors reveals spatial control of the sensitivity and kinetics of signal activation.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Trapping or slowing the diffusion of T cell receptors at close contacts initiates T cell signaling.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Biomechanical forces enhance directed migration and activation of bone marrow-derived dendritic cells.Scientific reports · 2021Article
- The Potential of Soluble Human Leukocyte Antigen Molecules for Early Cancer Detection and Therapeutic Vaccine Design.Vaccines · 2020Review
- Soluble MHC class I complexes for targeted immunotherapy.Life sciences · 2018Review
- Soluble major histocompatibility complex molecules in immune regulation: highlighting class II antigens.Immunology · 2018Review
- Linking form to function: Biophysical aspects of artificial antigen presenting cell design.Biochimica et biophysica acta · 2015Review
- Article
- SpyAvidin hubs enable precise and ultrastable orthogonal nanoassembly.Journal of the American Chemical Society · 2014Article
- Nanoscale artificial antigen presenting cells for T cell immunotherapy.Nanomedicine : nanotechnology, biology, and medicine · 2014Article
- Deletion of naïve T cells recognizing the minor histocompatibility antigen HY with toxin-coupled peptide-MHC class I tetramers inhibits cognate CTL responses and alters immunodominance.Transplant immunology · 2013Article
- Antibody-peptide-MHC fusion conjugates target non-cognate T cells to kill tumour cells.Cancer immunology, immunotherapy : CII · 2013Article
- Analysis, Isolation, and Activation of Antigen-Specific CD4(+) and CD8(+) T Cells by Soluble MHC-Peptide Complexes.Frontiers in immunology · 2013Article
- The use of peptide-major-histocompatibility-complex multimers in type 1 diabetes mellitus.Journal of diabetes science and technology · 2012Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
T cell receptor (TCR)-mediated activation of CD4(+) T cells is known to require multivalent engagement of the TCR by, for example, oligomeric peptide-MHC complexes. In contrast, for CD8(+) T cells, there is evidence for TCR-mediated activation by univalent engagement of the TCR. We have here compared oligomeric and monomeric L(d) and K(b) peptide-MHC complexes and free peptide as stimulators of CD8(+) T cells expressing the 2C TCR. We found that the monomers are indeed effective in activating naive and effector CD8(+) T cells, but through an unexpected mechanism that involves transfer of peptide from soluble monomers to T cell endogenous MHC (K(b)) molecules. The result is that T cells, acting as antigen-presenting cells, are able to activate other naive T cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.