ArticleJournal of bacteriology2002
Surface diversity in Mycoplasma agalactiae is driven by site-specific DNA inversions within the vpma multigene locus.
Article in Journal of bacteriology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 51 citations in OpenAlex.
- Comparative genomic analysis of Mycoplasma agalactiae strain GM139 highlights unique surface architecture and pathogenic determinants.Veterinary research · 2025Article
- Research Progress on Immune Evasion ofMicroorganisms · 2024Review
- Review
- Eating the Enemy: Mycoplasma Strategies to Evade Neutrophil Extracellular Traps (NETs) Promoting Bacterial Nucleotides Uptake and Inflammatory Damage.International journal of molecular sciences · 2022Review
- Serum Resistance ofPathogens (Basel, Switzerland) · 2022Article
- Sheep Infection Trials with 'Phase-Locked' Vpma Expression Variants ofMicroorganisms · 2022Article
- Predominant Single Stable VpmaV Expression in Strain GM139 and Major Differences withAnimals : an open access journal from MDPI · 2022Article
- Mycoplasma agalactiae ST35: a new sequence type with a minimal accessory genome primarily affecting goats.BMC veterinary research · 2022Article
- Minimalistic mycoplasmas harbor different functional toxin-antitoxin systems.PLoS genetics · 2021Article
- Genomic Islands in Mycoplasmas.Genes · 2020Review
- Molecular Mechanisms ofJournal of bacteriology · 2019Article
- Vpma phase variation is important for survival and persistence of Mycoplasma agalactiae in the immunocompetent host.PLoS pathogens · 2017Article
- Highly dynamic genomic loci drive the synthesis of two types of capsular or secreted polysaccharides within the Mycoplasma mycoides cluster.Applied and environmental microbiology · 2015Article
- In vitro and in vivo cell invasion and systemic spreading of Mycoplasma agalactiae in the sheep infection model.International journal of medical microbiology : IJMM · 2014Article
- Article
- Role of Vpma phase variation in Mycoplasma agalactiae pathogenesis.FEMS immunology and medical microbiology · 2012Article
- Unexpected genetic diversity of Mycoplasma agalactiae caprine isolates from an endemic geographically restricted area of Spain.BMC veterinary research · 2012Article
- Genome annotation of five Mycoplasma canis strains.Journal of bacteriology · 2012Article
- The Vsa shield of Mycoplasma pulmonis is antiphagocytic.Infection and immunity · 2012Article
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ruminant pathogen Mycoplasma agalactiae possesses a family of abundantly expressed variable surface lipoproteins called Vpmas. Phenotypic switches between Vpma members have previously been correlated with DNA rearrangements within a locus of vpma genes and are proposed to play an important role in disease pathogenesis. In this study, six vpma genes were characterized in the M. agalactiae type strain PG2. All vpma genes clustered within an 8-kb region and shared highly conserved 5' untranslated regions, lipoprotein signal sequences, and short N-terminal sequences. Analyses of the vpma loci from consecutive clonal isolates showed that vpma DNA rearrangements were site specific and that cleavage and strand exchange occurred within a minimal region of 21 bp located within the 5' untranslated region of all vpma genes. This process controlled expression of vpma genes by effectively linking the open reading frame (ORF) of a silent gene to a unique active promoter sequence within the locus. An ORF (xer1) immediately adjacent to one end of the vpma locus did not undergo rearrangement and had significant homology to a distinct subset of genes belonging to the lambda integrase family of site-specific xer recombinases. It is proposed that xer1 codes for a site-specific recombinase that is not involved in chromosome dimer resolution but rather is responsible for the observed vpma-specific recombination in M. agalactiae.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.