ArticleJournal of bacteriology2002
Evidence for a type III secretion system in Aeromonas salmonicida subsp. salmonicida.
Article in Journal of bacteriology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed, 106 citations in OpenAlex.
- Aeromonas in South Asia: genomic insights into an environmental pathogen and reservoir of antimicrobial resistance.Nature communications · 2026Article
- Cytotoxicity induced by Aeromonas schubertii is orchestrated by a unique set of type III secretion system effectors.Veterinary research · 2025Article
- Isolation, identification and characteristics ofFrontiers in microbiology · 2024Article
- Genome sequence of the virulentMicrobiology resource announcements · 2023Article
- Polyinfection in Fish Aeromoniasis: A Study of Co-IsolatedPathogens (Basel, Switzerland) · 2023Article
- Comparative Genomics Revealed a Potential Threat of Aeromonas rivipollensis G87 Strain and Its Antibiotic ResistanceAntibiotics (Basel, Switzerland) · 2023Article
- Effect of Iron Limitation, Elevated Temperature, and Florfenicol on the Proteome and Vesiculation of the Fish PathogenMicroorganisms · 2022Article
- Detection and distribution of virulence genes inVeterinary research forum : an international quarterly journal · 2022Article
- Comparative Genomics of Typical and AtypicalMicroorganisms · 2022Article
- Delivering the pain: an overview of the type III secretion system with special consideration for aquatic pathogens.Veterinary research · 2021Review
- Secretion Systems in Gram-Negative Bacterial Fish Pathogens.Frontiers in microbiology · 2021Review
- Comparative and Evolutionary Genomics of Isolates Provide Insight into the Pathoadaptation of Aeromonas.Genome biology and evolution · 2020Article
- An Update on the GenusMicroorganisms · 2020Review
- Immunoglobulin for Treating Bacterial Infections: One More Mechanism of Action.Antibodies (Basel, Switzerland) · 2019Review
- In Vitro and In Vivo Control of Secondary Bacterial Infection Caused by Leishmania major.International journal of environmental research and public health · 2017Article
- Plasmid composition in Aeromonas salmonicida subsp. salmonicida 01-B526 unravels unsuspected type three secretion system loss patterns.BMC genomics · 2017Article
- Epidemiology of DanishFrontiers in microbiology · 2017Article
- Subunit vaccine candidates against Aeromonas salmonicida in rainbow trout Oncorhynchus mykiss.PloS one · 2017Article
- Use of in vivo induced antigen technology to identify genes from Aeromonas salmonicida subsp. salmonicida that are specifically expressed during infection of the rainbow trout Oncorhynchus mykiss.BMC veterinary research · 2014Article
- Aeromonas salmonicida subsp. salmonicida in the light of its type-three secretion system.Microbial biotechnology · 2014Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aeromonas salmonicida subsp. salmonicida, the etiological agent of furunculosis, is an important fish pathogen. We have screened this bacterium with a broad-host-range probe directed against yscV, the gene that encodes the archetype of a highly conserved family of inner membrane proteins found in every known type III secretion system. This has led to the identification of seven open reading frames that encode homologues to proteins functioning within the type III secretion systems of Yersinia species. Six of these proteins are encoded by genes comprising a virA operon. The A. salmonicida subsp. salmonicida yscV homologue, ascV, was inactivated by marker replacement mutagenesis and used to generate an isogenic ascV mutant. Comparison of the extracellular protein profiles from the ascV mutant and the wild-type strain indicates that A. salmonicida subsp. salmonicida secretes proteins via a type III secretion system. The recently identified ADP-ribosylating toxin AexT was identified as one such protein. Finally, we have compared the toxicities of the wild-type A. salmonicida subsp. salmonicida strain and the ascV mutant against RTG-2 rainbow trout gonad cells. While infection with the wild-type strain results in significant morphological changes, including cell rounding, infection with the ascV mutant has no toxic effect, indicating that the type III secretion system we have identified plays an important role in the virulence of this pathogen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.