ArticleThe EMBO journal2002
Functions of LIM proteins in cell polarity and chemotactic motility.
Article in The EMBO journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- The Proteome ofProteomes · 2026Article
- Ultrastructural analysis of the morphological phenotypes of microglia associated with neuroinflammatory cues.The Journal of comparative neurology · 2022Article
- Microglia: Key Players in Retinal Ageing and Neurodegeneration.Frontiers in cellular neuroscience · 2022Review
- High nuclear expression of HIF1α, synergizing with inactivation of LIMD1 and VHL, portray worst prognosis among the bladder cancer patients: association with arsenic prevalence.Journal of cancer research and clinical oncology · 2021Article
- Review
- The Dictyostelium discoideum GPHR ortholog is an endoplasmic reticulum and Golgi protein with roles during development.Eukaryotic cell · 2015Article
- The centrosomal component CEP161 of Dictyostelium discoideum interacts with the Hippo signaling pathway.Cell cycle (Georgetown, Tex.) · 2015Article
- Functional manipulation of a calcium-binding protein from Entamoeba histolytica guided by paramagnetic NMR.The Journal of biological chemistry · 2013Article
- The cytohesin paralog Sec7 of Dictyostelium discoideum is required for phagocytosis and cell motility.Cell communication and signaling : CCS · 2013Article
- Drosophila melanogaster muscle LIM protein and alpha-actinin function together to stabilize muscle cytoarchitecture: a potential role for Mlp84B in actin-crosslinking.Cytoskeleton (Hoboken, N.J.) · 2013Article
- The evolutionary origin of epithelial cell-cell adhesion mechanisms.Current topics in membranes · 2013Article
- A cytohesin homolog in Dictyostelium amoebae.PloS one · 2010Article
- Contribution of the LIM domain and nebulin-repeats to the interaction of Lasp-2 with actin filaments and focal adhesions.PloS one · 2009Article
- CP250, a novel acidic coiled-coil protein of the Dictyostelium centrosome, affects growth, chemotaxis, and the nuclear envelope.Molecular biology of the cell · 2009Article
- EhLimA, a novel LIM protein, localizes to the plasma membrane in Entamoeba histolytica.Eukaryotic cell · 2007Article
- Article
- GrlJ, a Dictyostelium GABAB-like receptor with roles in post-aggregation development.BMC developmental biology · 2007Article
- Tobacco WLIM1 is a novel F-actin binding protein involved in actin cytoskeleton remodeling.The Plant cell · 2006Article
- A Rab21/LIM-only/CH-LIM complex regulates phagocytosis via both activating and inhibitory mechanisms.The EMBO journal · 2005Article
- The PXL1 gene of Saccharomyces cerevisiae encodes a paxillin-like protein functioning in polarized cell growth.Molecular biology of the cell · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
LimC and LimD are two novel LIM proteins of Dictyostelium, which are comprised of double and single LIM domains, respectively. Green fluorescent protein-fused LimC and LimD proteins preferentially accumulate at areas of the cell cortex where they co-localize with actin and associate transiently with cytoskeleton-dependent dynamic structures like phagosomes, macropinosomes and pseudopods. Furthermore, both LimC and LimD interact directly with F-actin in vitro. Mutant cells that lack either LimC or LimD, or both, exhibit normal growth. They are, however, significantly impaired in growth under stress conditions and are highly sensitive to osmotic shock, suggesting that LimC and LimD contribute towards the maintenance of cortical strength. Moreover, we noted an altered morphology and F-actin distribution in LimD(-) and LimC(-)/D(-) mutants, and changes in chemotactic motility associated with an increased pseudopod formation. Our results reveal both unique and overlapping roles for LimC and LimD, and suggest that both act directly on the actin cytoskeleton and provide rigidity to the cortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.