Evidence map›Paper›PMID 12373603›Full record

ArticleBritish journal of cancer2002

survivin messenger RNA expression is a good prognostic biomarker for oesophageal carcinoma.

M Ikeguchi, N Kaibara

Registry-linked trialOpen access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01556178 (Collection of Blood and Cerebrospinal Fluid for Pediatric Brain Tumor Research), which is not on this map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01556178 completednot on this mapstarted 2011, after this paper: background citation

Collection of Blood and Cerebrospinal Fluid for Pediatric Brain Tumor Research

TypeobservationalSponsorAnn & Robert H Lurie Children's Hospital of ChicagoRan2011 to 2012Enrolled5ConditionsHydrocephalus
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  6. Review
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  10. Clinical correlation of nuclear survivin in esophageal squamous cell carcinoma.Medical oncology (Northwood, London, England) · 2012
    Article
  11. High expression of survivin predicts poor prognosis in esophageal squamous cell carcinoma following radiotherapy.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2011
    Article
  12. Article
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  16. Review
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  18. Cellular localisation of survivin: impact on the prognosis in colorectal cancer.Journal of cancer research and clinical oncology · 2005
    Article
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

M IkeguchiFirst Department of Surgery, Faculty of Medicine, Tottori University, 36-1 Nishi-cho, Yonago 683-8504, Japan. masaike@grape.med.tottori-u.ac.jp
N Kaibara
Tottori University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oesophageal squamous cell carcinoma is one of the most malignant tumours. To identify patients with a high risk of recurrence of oesophageal squamous cell carcinoma, we investigated the prognostic significance of survivin mRNA expression in oesophageal squamous cell carcinoma, which has recently been reported to be a good marker for unfavourable prognosis in various tumours. Tumours and non-cancerous epitheliums adjacent to tumours were obtained by surgical resection from 57 patients with oesophageal squamous cell carcinoma. Expression levels of survivin and glyceraldehyde-3-phosphate dehydrogenase mRNA were analysed quantitatively by real-time reverse transcriptase polymerase chain reaction (RT-PCR). The survivin/glyceraldehyde-3-phosphate dehydrogenase ratios of tumours were higher than those of non-cancerous tissues (P=0.0003). Tumour-survivin/glyceraldehyde-3-phosphate dehydrogenase ratio did not correlate with histologic type, lymph node metastasis, and stage of tumours. In 53 surviving patients, the 5-year survival rate of 17 patients with high survivin mRNA expressed oesophageal squamous cell carcinoma (14.1%) was significantly poorer than that of 36 with low survivin mRNA expressed oesophageal squamous cell carcinoma (46.8%, P=0.0018). In these patients, tumour-survivin mRNA expression was recognised as a good marker of cancer recurrence independently from tumour stage. These findings indicate that survivin mRNA expression in oesophageal squamous cell carcinoma may be a good biomarker for identifying patients with high risk of cancer recurrence.

Indexed as

AgedAged, 80 and overAntigens, NeoplasmBiomarkers, TumorCarcinoma, Squamous CellDNA PrimersEsophageal NeoplasmsFemaleGlyceraldehyde 3-Phosphate Dehydrogenase (NADP+)HumansImmunoenzyme TechniquesInhibitor of Apoptosis ProteinsMaleMicrotubule-Associated ProteinsMiddle AgedNeoplasm ProteinsAntigens, NeoplasmBiomarkers, TumorBIRC5 protein, humanDNA PrimersGlyceraldehyde 3-Phosphate Dehydrogenase (NADP+)Inhibitor of Apoptosis ProteinsMicrotubule-Associated ProteinsNeoplasm ProteinsRNA, MessengerRNA, NeoplasmSurvivin

Identifiers

PMID12373603
PMCPMC2376173
OpenAlexW2045389765

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.