ArticleBritish journal of cancer2002
The association of breast mitogens with mammographic densities.
Article in British journal of cancer, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
120 citing papers in PubMed, 3 syntheses or guidelines pooled it, 277 citations in OpenAlex.
- Genetic architecture of mammographic density as a risk factor for breast cancer: a systematic review.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023Pooled it
- A comprehensive evaluation of interaction between genetic variants and use of menopausal hormone therapy on mammographic density.Breast cancer research : BCR · 2015Pooled it
- Mammographic density and risk of breast cancer by adiposity: an analysis of four case-control studies.International journal of cancer · 2012Pooled it
- Adolescent endogenous sex hormones and breast density in early adulthood.Breast cancer research : BCR · 2015Trial
- IGF1, IGFBP1, and IGFBP3 genes and mammographic density: the Multiethnic Cohort.International journal of cancer · 2010Trial
- Mammographic breast density and tolerance for short-term postmenopausal hormone therapy suspension.Journal of women's health (2002) · 2010Trial
- Steroid hormone metabolites and mammographic breast density in premenopausal women.British journal of cancer · 2026Article
- Association Between Baseline Mammographic Breast Density and the Incidence of Natural Menopause in Korean Women: A Nationwide Population-Based Study Using National Health Screening Data.International journal of women's health · 2026Article
- Early thelarche, reproductive hormones, and MRI-based breast density: a prospective study in China.Breast cancer research : BCR · 2025Article
- Circulating sex hormones and volumetric breast density: A prospective study in women from the EPIC Florence cohort.International journal of cancer · 2025Article
- Association between mammographic breast density and outcome in patients with unilateral invasive breast cancer receiving neoadjuvant chemotherapy.Breast cancer research and treatment · 2025Observational
- Plasma prolactin and postmenopausal breast cancer risk: a pooled analysis of four prospective cohort studies.Breast cancer research : BCR · 2024Article
- Disentangling the relationships of body mass index and circulating sex hormone concentrations in mammographic density using Mendelian randomization.Breast cancer research and treatment · 2024Article
- The Prospective Association between Early Life Growth and Breast Density in Young Adult Women.Cancers · 2024Article
- Breast cancer risk factors and mammographic density among 12518 average-risk women in rural China.BMC cancer · 2023Article
- Lifetime changes in body fatness and breast density in postmenopausal women: the FEDRA study.Breast cancer research : BCR · 2023Article
- A genome-wide association study of mammographic texture variation.Breast cancer research : BCR · 2022Article
- The association of age at menarche and adult height with mammographic density in the International Consortium of Mammographic Density.Breast cancer research : BCR · 2022Article
- Changes in adiposity over the life course and gene expression in postmenopausal women.Cancer medicine · 2022Article
- Plasma Growth Factor Gene Expression and Mammographic Breast Density in Postmenopausal Women.Cancer prevention research (Philadelphia, Pa.) · 2022Article
60 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Radiologically dense breast tissue (mammographic density) is strongly associated with risk of breast cancer, but the biological basis for this association is unknown. In this study we have examined the association of circulating levels of hormones and growth factors with mammographic density. A total of 382 subjects, 193 premenopausal and 189 postmenopausal, without previous breast cancer or current hormone use, were selected in each of five categories of breast density from mammography units. Risk factor information, anthropometric measures, and blood samples were obtained, and oestradiol, progesterone, sex hormone binding globulin, growth hormone, insulin-like growth factor-I and its principal binding protein, and prolactin measured. Mammograms were digitised and measured using a computer-assisted method. After adjustment for other risk factors, we found in premenopausal women that serum insulin-like growth factor-I levels, and in postmenopausal women, serum levels of prolactin, were both significantly and positively associated with per cent density. Total oestradiol and progesterone levels were unrelated to per cent density in both groups. In postmenopausal women, free oestradiol (negatively), and sex hormone binding globulin (positively), were significantly related to per cent density. These data show an association between blood levels of breast mitogens and mammographic density, and suggest a biological basis for the associated risk of breast cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.