ArticleGenome biology2002
Conservation of long-range synteny and microsynteny between the genomes of two distantly related nematodes.
Article in Genome biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 69 citations in OpenAlex.
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- The genomic basis of nematode parasitism.Briefings in functional genomics · 2018Review
- Genome Architecture and Evolution of a Unichromosomal Asexual Nematode.Current biology : CB · 2017Article
- Synteny Portal: a web-based application portal for synteny block analysis.Nucleic acids research · 2016Article
- The genome and transcriptome of Haemonchus contortus, a key model parasite for drug and vaccine discovery.Genome biology · 2013Article
- The draft genome of the parasitic nematode Trichinella spiralis.Nature genetics · 2011Article
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- The putative cyclooctadepsipeptide receptor depsiphilin of the canine hookworm Ancylostoma caninum.Parasitology research · 2009Article
- Genes encoding putative biogenic amine receptors in the parasitic nematode Brugia malayi.Invertebrate neuroscience : IN · 2007Article
- Functional and evolutionary analysis of alternatively spliced genes is consistent with an early eukaryotic origin of alternative splicing.BMC evolutionary biology · 2007Article
- Draft genome of the filarial nematode parasite Brugia malayi.Science (New York, N.Y.) · 2007Article
- Comparison of C. elegans and C. briggsae genome sequences reveals extensive conservation of chromosome organization and synteny.PLoS biology · 2007Article
- Operon conservation and the evolution of trans-splicing in the phylum Nematoda.PLoS genetics · 2006Article
- Very little intron loss/gain in Plasmodium: intron loss/gain mutation rates and intron number.Genome research · 2006Article
- Origins of recently gained introns in Caenorhabditis.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Macrophage migration inhibitory factor: a regulator of innate immunity.Nature reviews. Immunology · 2003Review
- Limited microsynteny between the genomes of Pristionchus pacificus and Caenorhabditis elegans.Nucleic acids research · 2003Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundComparisons between the genomes of the closely related nematodes Caenorhabditis elegans and Caenorhabditis briggsae reveal high rates of rearrangement, with a bias towards within-chromosome events. To assess whether this pattern is true of nematodes in general, we have used genome sequence to compare two nematode species that last shared a common ancestor approximately 300 million years ago: the model C. elegans and the filarial parasite Brugia malayi.
resultsAn 83 kb region flanking the gene for Bm-mif-1 (macrophage migration inhibitory factor, a B. malayi homolog of a human cytokine) was sequenced. When compared to the complete genome of C. elegans, evidence for conservation of long-range synteny and microsynteny was found. Potential C. elegans orthologs for II of the 12 protein-coding genes predicted in the B. malayi sequence were identified. Ten of these orthologs were located on chromosome I, with eight clustered in a 2.3 Mb region. While several, relatively local, intrachromosomal rearrangements have occurred, the order, composition, and configuration of two gene clusters, each containing three genes, was conserved. Comparison of B. malayi BAC-end genome survey sequence to C. elegans also revealed a bias towards intrachromosome rearrangements.
conclusionsWe suggest that intrachromosomal rearrangement is a major force driving chromosomal organization in nematodes, but is constrained by the interdigitation of functional elements of neighboring genes.
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