ArticleOncogene2002
Oncogenic transformation by beta-catenin: deletion analysis and characterization of selected target genes.
Article in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Oncometabolite 5-IPNature chemical biology · 2026Article
- The Key Role of IPMolecules (Basel, Switzerland) · 2020Review
- Differential regulation of myc homologs by Wnt/β-Catenin signaling in the early metazoan Hydra.The FEBS journal · 2019Article
- Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Obesity and cancer risk: evidence, mechanisms, and recommendations.Annals of the New York Academy of Sciences · 2012Review
- The GM-CSF receptor utilizes β-catenin and Tcf4 to specify macrophage lineage differentiation.Differentiation; research in biological diversity · 2012Article
- Smooth muscle α-actin is a direct target of PLZF: effects on the cytoskeleton and on susceptibility to oncogenic transformation.Oncotarget · 2010Article
- Inositol pyrophosphates: structure, enzymology and function.Cellular and molecular life sciences : CMLS · 2009Review
- Posttranslational regulation of Myc by promyelocytic leukemia zinc finger protein.International journal of cancer · 2009Article
- Discovery of inhibitors of aberrant gene transcription from Libraries of DNA binding molecules: inhibition of LEF-1-mediated gene transcription and oncogenic transformation.Journal of the American Chemical Society · 2009Article
- Direct interaction of tumor suppressor CEACAM1 with beta catenin: identification of key residues in the long cytoplasmic domain.Experimental biology and medicine (Maywood, N.J.) · 2008Article
- Wnt activation and alternative promoter repression of LEF1 in colon cancer.Molecular and cellular biology · 2006Article
- Inhibition of protein synthesis by Y box-binding protein 1 blocks oncogenic cell transformation.Molecular and cellular biology · 2005Article
- Targets of fibroblast growth factor 1 (FGF-1) and FGF-2 signaling involved in the invasive and tumorigenic behavior of carcinoma cells.Molecular biology of the cell · 2004Article
- Beta-catenin regulation during the cell cycle: implications in G2/M and apoptosis.Molecular biology of the cell · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Genetic analysis of beta-catenin-induced oncogenic transformation in chicken embryo fibroblasts (CEF) revealed the following prerequisites for oncogenicity: (1) removal of the N terminal phosphorylation sites targeted by glycogen synthase kinase 3beta (GSK3beta), (2) retention of the N terminal transactivation domain, and (3) retention of the armadillo repeats. The C terminal transactivation domain played an ancillary role in the transformation of CEF. There was a rough correlation between the transforming activity of various beta-catenin constructs and their transactivation of the TOPFLASH reporter. Expression levels of the candidate target genes of beta-catenin-LEF, cyclin D1 and myc were not correlated with each other or with the transforming activity of beta-catenin constructs. A new target gene, coding for inositol hexakisphosphate kinase 2 (IP6K2) was identified. Its expression showed concordance with the transforming activity of beta-catenin constructs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.