ArticleOncogene2002
Genomic instability driven by the human T-cell leukemia virus type I (HTLV-I) oncoprotein, Tax.
Article in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Insights into oncovirus-driven tumor dynamics: a perspective from intravital imaging.Frontiers in cell and developmental biology · 2026Review
- Review
- Article
- HTLV-1 Infection and Adult T-Cell Leukemia/Lymphoma-A Tale of Two Proteins: Tax and HBZ.Viruses · 2016Review
- Human T-cell leukemia virus type 1 Tax oncoprotein represses the expression of the BCL11B tumor suppressor in T-cells.Cancer science · 2015Article
- Human viruses and cancer.Viruses · 2014Review
- Activation of WIP1 phosphatase by HTLV-1 Tax mitigates the cellular response to DNA damage.PloS one · 2013Article
- Mitochondrial alteration in malignantly transformed human small airway epithelial cells induced by α-particles.International journal of cancer · 2013Article
- The HTLV-1 Tax oncoprotein represses Ku80 gene expression.Virology · 2011Article
- Review
- View and review on viral oncology research.Infectious agents and cancer · 2010Article
- Human T-cell leukemia virus type 1 infection leads to arrest in the G1 phase of the cell cycle.Journal of virology · 2008Article
- Human T-cell leukemia virus type 1 tax attenuates the ATM-mediated cellular DNA damage response.Journal of virology · 2008Article
- Human T Lymphotropic Virus Type 1 protein Tax reduces histone levels.Retrovirology · 2008Article
- Genotoxic stress and cellular stress alter the subcellular distribution of human T-cell leukemia virus type 1 tax through a CRM1-dependent mechanism.Journal of virology · 2006Article
- Impact of HTLV-I Tax on cell cycle progression and the cellular DNA damage repair response.Oncogene · 2005Review
- T-cell control by human T-cell leukemia/lymphoma virus type 1.International journal of hematology · 2003Review
- Neoplastic transformation of human small airway epithelial cells induced by arsenic.Molecular medicine (Cambridge, Mass.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The importance of maintaining genomic stability is evidenced by the fact that transformed cells often contain a variety of chromosomal abnormalities such as euploidy, translocations, and inversions. Gene amplification is a well-characterized hallmark of genomic instability thought to result from recombination events following the formation of double-strand, chromosomal breaks. Therefore, gene amplification frequency serves as an indicator of genomic stability. The PALA assay is designed to measure directly the frequency with which a specific gene, CAD, is amplified within a cell's genome. We have used the PALA assay to analyse the effects of the human T-cell leukemia virus type I (HTLV-I) oncoprotein, Tax, on genomic amplification. We demonstrate that Tax-expressing cells are five-times more likely to undergo gene amplification than control cells. Additionally, we show that Tax alters the ability of cells to undergo the typical PALA-mediated G(1) phase cell cycle arrest, thereby allowing cells to replicate DNA in the absence of appropriate nucleotide pools. This effect is likely the mechanism by which Tax induces gene amplification. These data suggest that HTLV-I Tax alters the genomic stability of cells, an effect that may play an important role in Tax-mediated, HTLV-I associated cellular transformation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.