ArticleOncogene2002
Stabilization of p53 and transactivation of its target genes in response to replication blockade.
Article in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- The Roles of P53 and Its Family Proteins, P63 and P73, in the DNA Damage Stress Response in Organogenesis-Stage Mouse Embryos.Toxicological sciences : an official journal of the Society of Toxicology · 2018Article
- Article
- Histone modifications and p53 binding poise the p21 promoter for activation in human embryonic stem cells.Scientific reports · 2016Article
- A reduction of licensed origins reveals strain-specific replication dynamics in mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Article
- Cyclin-dependent kinase activity controls the onset of the HCMV lytic cycle.PLoS pathogens · 2010Article
- p53- and p21-dependent premature APC/C-Cdh1 activation in G2 is part of the long-term response to genotoxic stress.Oncogene · 2010Article
- Article
- Relationship between VEGF and p53 expression and tumor cell proliferation in human gastrointestinal carcinomas.Journal of cancer research and clinical oncology · 2008Article
- p53 mediates senescence-like arrest induced by chronic replicational stress.Molecular and cellular biology · 2007Article
- p53-Dependent p21 mRNA elongation is impaired when DNA replication is stalled.Molecular and cellular biology · 2007Article
- Drosophila dCBP is involved in establishing the DNA replication checkpoint.Molecular and cellular biology · 2007Article
- Differential regulation of human YY1 and caspase 7 promoters by prohibitin through E2F1 and p53 binding sites.The Biochemical journal · 2007Article
- Suppression of replication fork progression in low-dose-specific p53-dependent S-phase DNA damage checkpoint.Oncogene · 2006Article
- Transcription factor YY1: structure, function, and therapeutic implications in cancer biology.Oncogene · 2006Review
- Induction of p19INK4d in response to ultraviolet light improves DNA repair and confers resistance to apoptosis in neuroblastoma cells.Oncogene · 2005Article
- Transcription-independent suppression of DNA synthesis by p53 in sperm-irradiated mouse zygotes.Oncogene · 2005Article
- Article
- Domain organization of the yeast histone chaperone FACT: the conserved N-terminal domain of FACT subunit Spt16 mediates recovery from replication stress.Nucleic acids research · 2004Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Although it is clear that p53 plays a pivotal role in G1/G2 checkpoints to conserve genomic integrity, its role in S phase checkpoint is less well understood. Recently, it has been reported that p53 is transcriptionally impaired even though it is stabilized during replication blockade. However, the mechanisms underlying this phenomenon are not known. In the present study, it has been shown that p53 accumulates and transactivates its target genes such as p21, gadd45 and bax in response to replication blockade in normal and cancer cells. Lack of transcriptional activation under similar conditions in cells lacking p53 shows that p53-target gene activation during replication blockade is indeed p53-dependent. Further, transactivation of p21 in response to replication blockade by hydroxyurea and aphidicolin is similar to that in response to ionizing radiation except that the latter is more immediate compared to the response to replication blockade. These findings suggest that impairment of transcriptionally active p53 in response to replication blockade is not a general phenomenon.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.