ArticleProceedings of the National Academy of Sciences of the United States of America2002
Identification of a localization factor for the polar positioning of bacterial structural and regulatory proteins.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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Who cites it
77 citing papers in PubMed, 152 citations in OpenAlex.
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- Construction and phenotypic classification of synthetic dual-pole Escherichia coli cells.Communications biology · 2025Article
- Biomolecular condensates as stress sensors and modulators of bacterial signaling.PLoS pathogens · 2024Review
- Phosphatase to kinase switch of a critical enzyme contributes to timing of cell differentiation.mBio · 2024Article
- Scaffold-Scaffold Interaction Facilitates Cell Polarity Development in Caulobacter crescentus.mBio · 2023Article
- Phase separation modulates the assembly and dynamics of a polarity-related scaffold-signaling hub.Nature communications · 2022Article
- Computational modeling of unphosphorylated CtrA:iScience · 2021Article
- Article
- Article
- Review
- A localized adaptor protein performs distinct functions at theProceedings of the National Academy of Sciences of the United States of America · 2021Article
- The polar Ras-like GTPase MglA activates type IV pilus via SgmX to enable twitching motility inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Segregation of fourProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Surface sensing stimulates cellular differentiation inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Integrative and quantitative view of the CtrA regulatory network in a stalked budding bacterium.PLoS genetics · 2020Article
- Article
- Article
- GROWTH POLE RING protein forms a 200-nm-diameter ring structure essential for polar growth and rod shape inProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Reciprocal control of motility and biofilm formation by the PdhS2 two-component sensor kinase of Agrobacterium tumefaciens.Microbiology (Reading, England) · 2019Article
17 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Polar pili biogenesis in Caulobacter involves the asymmetric localization of the CpaE and CpaC components of the pili-specific secretion apparatus to one pole of the predivisional cell followed by the biosynthesis of the pili filaments in the daughter swarmer cell. The histidine kinase signaling protein, PleC, that controls the temporal accumulation of the PilA pilin subunit is asymmetrically localized to the pole at which pili are assembled. Here we identify a protein, PodJ, that provides the positional information for the polar localization of both PleC and CpaE. The PodJ protein was found to exist in two forms, a truncated 90-kDa and a full-length 110-kDa form, each controlling a different aspect of polar development and each localizing to the cell poles at a specific time in the cell cycle. When active PleC is delocalized in a DeltapodJ mutant, the accumulation of PilA, the downstream target of PleC signaling, is impaired, providing evidence that the polar localization of this histidine kinase stimulates the response signaled by a two-component system.
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