ArticleProceedings of the National Academy of Sciences of the United States of America2002
The origin of a developmentally regulated Igh replicon is located near the border of regulatory domains for Igh replication and expression.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 47 citations in OpenAlex.
- Complex sex-biased antibody responses: estrogen receptors bind estrogen response elements centered within immunoglobulin heavy chain gene enhancers.International immunology · 2019Article
- Nonlinear expression and visualization of nonmetric relationships in genetic diseases and microbiome data.BMC bioinformatics · 2018Article
- Mapping of Replication Origins in the X Inactivation Center of Vole Microtus levis Reveals Extended Replication Initiation Zone.PloS one · 2015Article
- ATM deficiency augments constitutively nuclear cyclin D1-driven genomic instability and lymphomagenesis.Oncogene · 2014Article
- Epigenetic Regulation of Individual Modules of the immunoglobulin heavy chain locus 3' Regulatory Region.Frontiers in immunology · 2014Review
- Germline deletion of Igh 3' regulatory region elements hs 5, 6, 7 (hs5-7) affects B cell-specific regulation, rearrangement, and insulation of the Igh locus.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- The role of CTCF binding sites in the 3' immunoglobulin heavy chain regulatory region.Frontiers in genetics · 2012Article
- Genome-wide depletion of replication initiation events in highly transcribed regions.Genome research · 2011Article
- Pre-replication complex proteins assemble at regions of low nucleosome occupancy within the Chinese hamster dihydrofolate reductase initiation zone.Nucleic acids research · 2011Article
- Decreased replication origin activity in temporal transition regions.The Journal of cell biology · 2009Article
- The concerted action of Msh2 and UNG stimulates somatic hypermutation at A . T base pairs.Molecular and cellular biology · 2009Article
- Chromatin state marks cell-type- and gender-specific replication of the Drosophila genome.Genes & development · 2009Article
- Pax5 and linker histone H1 coordinate DNA methylation and histone modifications in the 3' regulatory region of the immunoglobulin heavy chain locus.Molecular and cellular biology · 2008Article
- Article
- Changes in replication, nuclear location, and expression of the Igh locus after fusion of a pre-B cell line with a T cell line.Journal of immunology (Baltimore, Md. : 1950) · 2005Article
- Sites that direct nuclear compartmentalization are near the 5' end of the mouse immunoglobulin heavy-chain locus.Molecular and cellular biology · 2005Article
- Chromatin architecture near a potential 3' end of the igh locus involves modular regulation of histone modifications during B-Cell development and in vivo occupancy at CTCF sites.Molecular and cellular biology · 2005Article
- In search of the holy replicator.Nature reviews. Molecular cell biology · 2004Review
- Review
- Plasticity of DNA replication initiation in Epstein-Barr virus episomes.PLoS biology · 2004Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
The 3' Ig heavy chain locus (Igh) regulatory region is the most downstream known element of the murine Igh gene cluster. We report here that the nearest non-Igh genes-Crip, Crp2, and Mta1-are located approximately 70 kb further downstream and are beyond the end of the domain of Igh transcriptional regulation. We have localized an origin of replication in MEL cells to a 3-kb segment located between the 3' Igh regulatory region and Crip. Sequences downstream of this origin are replicated by forks that move in both directions. Sequences upstream of this origin (Igh-C, -D, and -J) are replicated in a single direction through a 500-kb segment in which no active bidirectional origins can be detected. We propose that this origin may lie at or near the end of the Igh regulation domain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.