ArticleProceedings of the National Academy of Sciences of the United States of America2002
Genomewide analysis of the Drosophila tetraspanins reveals a subset with similar function in the formation of the embryonic synapse.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 67 citations in OpenAlex.
- Characterisation of extracellular vesicles in baculovirus infection ofJournal of extracellular biology · 2024Article
- Microscopic and biochemical monitoring of endosomal trafficking and extracellular vesicle secretion in an endogenous in vivo model.Journal of extracellular vesicles · 2022Article
- A conserved sequence in the small intracellular loop of tetraspanins forms an M-shaped inter-helix turn.Scientific reports · 2022Article
- The CD63 homologs, Tsp42Ee and Tsp42Eg, restrict endocytosis and promote neurotransmission through differential regulation of synaptic vesicle pools.Frontiers in cellular neuroscience · 2022Article
- Tetraspanins as Potential Modulators of Glutamatergic Synaptic Function.Frontiers in molecular neuroscience · 2021Review
- Genome-Wide Screen for New Components of theG3 (Bethesda, Md.) · 2018Article
- Review
- Diversification of spatiotemporal expression and copy number variation of the echinoid hbox12/pmar1/micro1 multigene family.PloS one · 2017Article
- Article
- Functional Analysis of the Arabidopsis TETRASPANIN Gene Family in Plant Growth and Development.Plant physiology · 2015Article
- Multispecies Analysis of Expression Pattern Diversification in the Recently Expanded Insect Ly6 Gene Family.Molecular biology and evolution · 2015Article
- Changes in organelle position and epithelial architecture associated with loss of CrebA.Biology open · 2015Article
- Evolution and Structural Analyses of Glossina morsitans (Diptera; Glossinidae) Tetraspanins.Insects · 2014Article
- CD9 negatively regulates CD26 expression and inhibits CD26-mediated enhancement of invasive potential of malignant mesothelioma cells.PloS one · 2014Article
- Mass spectrometry based proteomic analysis of salivary glands of urban malaria vector Anopheles stephensi.BioMed research international · 2014Article
- IgSF8: a developmentally and functionally regulated cell adhesion molecule in olfactory sensory neuron axons and synapses.Molecular and cellular neurosciences · 2012Article
- Identification and characterization of six novel tetraspanins from Schistosoma japonicum.Parasites & vectors · 2011Article
- MAL/VIP17, a new player in the regulation of NKCC2 in the kidney.Molecular biology of the cell · 2010Article
- A conserved tetraspanin subfamily promotes Notch signaling in Caenorhabditis elegans and in human cells.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Genetical toxicogenomics in Drosophila identifies master-modulatory loci that are regulated by developmental exposure to lead.Neurotoxicology · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tetraspanins encode a large conserved family of proteins that span the membrane four times and are expressed in a variety of eukaryotic tissues. They are part of membrane complexes that are involved in such diverse processes as intracellular signaling, cellular motility, metastasis, and tumor suppression. The single fly tetraspanin characterized to date, late bloomer (lbm), is expressed on the axons, terminal arbors, and growth cones of motoneurons. In embryos lacking Lbm protein, motoneurons reach their muscle targets, but initially fail to form synaptic terminals. During larval stages, however, functional contacts are formed. The newly available genomic sequence of Drosophila melanogaster indicates the existence of 34 additional members of the tetraspanin family in the fly. To address the possibility that other tetraspanins with functions that might compensate for a lack of lbm exist, we determined the expression domains of the Drosophila tetraspanin gene family members by RNA in situ analysis. We found two other tetraspanins also expressed in motoneurons and subsequently generated a small chromosomal deletion that removes all three motoneuron-specific tetraspanins. The deletion results in a significant enhancement in the lbm phenotype, indicating that the two additional motoneuron-expressed tetraspanins can, at least in part, compensate for the absence of lbm during the formation of the embryonic synapse.
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