ArticleThe Journal of cell biology2002
Both midzone and astral microtubules are involved in the delivery of cytokinesis signals: insights from the mobility of aurora B.
Article in The Journal of cell biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 106 citations in OpenAlex.
- Kinetochore-microtubule error correction for biorientation: lessons from yeast.Biochemical Society transactions · 2024Review
- Article
- PLK1 plays dual roles in centralspindlin regulation during cytokinesis.The Journal of cell biology · 2019Article
- Aurora kinase B regulates axonal outgrowth and regeneration in the spinal motor neurons of developing zebrafish.Cellular and molecular life sciences : CMLS · 2018Article
- Atypical Cadherin Dachsous1b Interacts with Ttc28 and Aurora B to Control Microtubule Dynamics in Embryonic Cleavages.Developmental cell · 2018Article
- Augmin shapes the anaphase spindle for efficient cytokinetic furrow ingression and abscission.Molecular biology of the cell · 2016Article
- Article
- Spindle-to-cortex communication in cleaving, polyspermic Xenopus eggs.Molecular biology of the cell · 2015Article
- The Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint Signaling.Frontiers in oncology · 2015Review
- The chromosomal passenger complex (CPC) as a key orchestrator of orderly mitotic exit and cytokinesis.Frontiers in cell and developmental biology · 2015Review
- An astral simulacrum of the central spindle accounts for normal, spindle-less, and anucleate cytokinesis in echinoderm embryos.Molecular biology of the cell · 2014Article
- Review
- SHCBP1 is required for midbody organization and cytokinesis completion.Cell cycle (Georgetown, Tex.) · 2014Article
- Article
- Emergent complexity of the cytoskeleton: from single filaments to tissue.Advances in physics · 2013Review
- Localization of cytokinesis factors to the future cell division site by microtubule-dependent transport.Cytoskeleton (Hoboken, N.J.) · 2012Article
- Centralspindlin and chromosomal passenger complex behavior during normal and Rappaport furrow specification in echinoderm embryos.Cytoskeleton (Hoboken, N.J.) · 2012Article
- Plk1 negatively regulates PRC1 to prevent premature midzone formation before cytokinesis.Molecular biology of the cell · 2012Article
- Review
- Midbody assembly and its regulation during cytokinesis.Molecular biology of the cell · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
To address the mechanism that coordinates cytokinesis with mitosis, we have studied the dynamics of aurora B, a chromosomal passenger protein involved in signaling cytokinesis. Photobleaching analyses indicated dynamic exchange of aurora B between a centromeric and a cytoplasmic pool before anaphase onset, and stable associations with microtubules after anaphase onset. Bleaching near centromeres upon anaphase onset affected the subsequent appearance of fluorescence along midzone microtubules, but not that near the lateral equatorial cortex, suggesting that there were centromeric-dependent and -independent pathways that transported aurora B to the equator. The former delivered centromeric aurora B along midzone microtubules, whereas the latter delivered cytoplasmic aurora B along astral microtubules. We suggest that cultured cells use midzone microtubules as the primary signaling pathway for cytokinesis, whereas embryos, with their stockpile of cytoplasmic proteins and large sizes, rely primarily on astral microtubules.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.