Trial reportAnnals of surgery2002
Beta-blockade and growth hormone after burn.
Trial report in Annals of surgery, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- The effectiveness and safety of beta antagonist in burned patients: A systematic review and meta-analysis.International wound journal · 2020Pooled it
- Quantification of an Exercise Rehabilitation Program for Severely Burned Children: The Standard of Care at Shriners Hospitals for Children®-Galveston.Journal of burn care & research : official publication of the American Burn Association · 2018Guideline
- Recombinant human growth hormone for treating burns and donor sites.The Cochrane database of systematic reviews · 2014Pooled it
- Reduced Postburn Hypertrophic Scarring and Improved Physical Recovery With Yearlong Administration of Oxandrolone and Propranolol.Annals of surgery · 2018Trial
- Nutrition in Pediatric Burns.Seminars in plastic surgery · 2024Review
- Pathological changes in the brain after peripheral burns.Burns & trauma · 2023Review
- Rehabilitative Exercise Training for Burn Injury.Sports medicine (Auckland, N.Z.) · 2021Review
- A narrative review of skeletal muscle atrophy in critically ill children: pathogenesis and chronic sequelae.Translational pediatrics · 2021Review
- Anabolic and anticatabolic agents used in burn care: What is known and what is yet to be learned.Burns : journal of the International Society for Burn Injuries · 2020Review
- Determinants of skeletal muscle protein turnover following severe burn trauma in children.Clinical nutrition (Edinburgh, Scotland) · 2019Observational
- The Role of Mitochondrial Stress in Muscle Wasting Following Severe Burn Trauma.Journal of burn care & research : official publication of the American Burn Association · 2018Review
- Children with Burn Injury Have Impaired Cardiac Output during Submaximal Exercise.Medicine and science in sports and exercise · 2017Article
- The P50 Research Center in Perioperative Sciences: How the investment by the National Institute of General Medical Sciences in team science has reduced postburn mortality.The journal of trauma and acute care surgery · 2017Article
- Anabolic and anticatabolic agents in critical care.Current opinion in critical care · 2016Review
- The impact of severe burns on skeletal muscle mitochondrial function.Burns : journal of the International Society for Burn Injuries · 2013Review
- Whole body and skeletal muscle protein turnover in recovery from burns.International journal of burns and trauma · 2013Article
- The effect of β-adrenergic blockade and COX-2 inhibition on healing of colon, muscle, and skin in rats undergoing colonic anastomosis.International journal of clinical pharmacology and therapeutics · 2011Article
- What, how, and how much should patients with burns be fed?The Surgical clinics of North America · 2011Review
- The hypermetabolic response to burn injury and interventions to modify this response.Clinics in plastic surgery · 2009Review
- Modulation of the hypermetabolic response to trauma: temperature, nutrition, and drugs.Journal of the American College of Surgeons · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo determine whether propranolol and growth hormone (GH) have additive effects to combat burn-induced catabolism. SUMMARY BACKGROUND DATA: Both GH and propranolol have been attributed anabolic properties after severe trauma and burn. It is conceivable that the two in combination would have additive effects.
methodsFifty-six children with more than 40% TBSA burns were randomized to one of four anabolic regimens: untreated control, GH treatment, propranolol treatment, or combination GH plus propranolol therapy. Clinical treatment was identical for all groups. Resting energy expenditure was determined by indirect calorimetry and skeletal muscle protein kinetics were measured using stable amino acid isotope infusions before and after each anabolic regimen.
resultsThere were no differences in age, sex, or burn size between groups. Tachycardia and energy expenditure were decreased during propranolol treatment ( <.05). The net balance of muscle protein synthesis and breakdown was improved during propranolol and GH plus propranolol treatment ( <.05). There was no significant benefit of GH alone. No additive effect of combination therapy was seen.
conclusionsPropranolol is a strongly anabolic drug during the early, hypercatabolic period after burn. No synergistic effect between propranolol and GH was identified.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.