ArticleThe Laryngoscope2002
Relative risk of stroke in head and neck carcinoma patients treated with external cervical irradiation.
Article in The Laryngoscope, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02114697 (Accelerated Atherosclerosis in High Risk Population Groups), which is not on this map. Cited by 43 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Accelerated Atherosclerosis in High Risk Population Groups: An Assessment by Magnetic Resonance Imaging
Who cites it
43 citing papers in PubMed, 6 syntheses or guidelines pooled it, 116 citations in OpenAlex.
- Stroke Risk in Head and Neck Cancer: A Meta-analysis of Reconstructed Individual Patient Survival Data.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025Pooled it
- Role of Preoperative Embolization in Surgical Management of Carotid Body Tumors: A Systematic Review and Meta-Analysis.Angiology · 2025Pooled it
- Intensity-Modulated Radiation Therapy for Early-Stage Squamous Cell Carcinoma of the Glottic Larynx: A Systematic Review and Meta-Analysis.International journal of radiation oncology, biology, physics · 2023Pooled it
- Is stroke incidence increased in survivors of adult cancers? A systematic review and meta-analysis.Journal of cancer survivorship : research and practice · 2022Pooled it
- Risk of CVD Following Radiotherapy for Head and Neck Cancer: An Updated Systematic Review and Meta-Analysis.Frontiers in oncology · 2022Pooled it
- Radiotherapy Exposure in Cancer Patients and Subsequent Risk of Stroke: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2019Pooled it
- Prospective, Randomized Study of Radiation Dose Escalation With Combined Proton-Photon Therapy for Benign Meningiomas.International journal of radiation oncology, biology, physics · 2017Trial
- An investigation of intensity-modulated radiation therapy versus conventional two-dimensional and 3D-conformal radiation therapy for early stage larynx cancer.Radiation oncology (London, England) · 2010Trial
- Diagnostic Performance of Duplex Ultrasonography in Post-Radiation Common Carotid Artery Stenosis: A Cross-Sectional Validation Study.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026Article
- Radiation-Induced Carotid Artery Disease: Pathogenesis, Diagnosis and Management.Diagnostics (Basel, Switzerland) · 2026Review
- The impact of different types of radiotherapy on cerebrovascular-specific death in patients with thyroid malignant tumors.Discover oncology · 2025Article
- Post-irradiation vertebral and carotid stenosis heightens stroke risk in head and neck cancer.BMC cancer · 2025Observational
- Radiation Vasculopathy.Cerebrovascular diseases extra · 2025Review
- Stroke Risk in Survivors of Head and Neck Cancer.JAMA network open · 2024Article
- Stroke death in patients receiving radiation for head and neck cancer in the modern era.Frontiers in oncology · 2023Article
- Application of Carotid Duplex Ultrasonography in the Surveillance of Carotid Artery Stenosis after Neck Irradiation.Reviews in cardiovascular medicine · 2022Review
- Increased risk of cerebrovascular mortality in head and neck cancer survivors aged ≥ 65 years treated with definitive radiotherapy: a population-based cohort study.Radiation oncology (London, England) · 2021Article
- Radiation-Induced Vascular Disease-A State-of-the-Art Review.Frontiers in cardiovascular medicine · 2021Review
- Vascular events from carotid artery atherosclerosis after radiation therapy for laryngeal and hypopharyngeal cancer: the incidence and risk factors.Nagoya journal of medical science · 2020Article
- Outcomes of carotid-sparing IMRT for T1 glottic cancer: Comparison with conventional radiation.The Laryngoscope · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the rate of cerebrovascular events (stroke) in patients irradiated to high doses for squamous cell carcinoma of the head and neck. STUDY
designRetrospective chart review of 413 patients treated from 1987 to 2000 with squamous cell carcinoma of the head and neck was performed to determine the risk of stroke compared with the expected rate.
methodsSurgical, radiotherapeutic, radiological, and clinical or office records of 413 patients were analyzed, and data were collected regarding clinical risk factors for stroke, irradiation parameters, and follow-up on whether or not a stroke event occurred. The actuarial risk of stroke for this population was calculated and compared with expected risk from population-based data.
resultsOf the 413 patients, 20 had strokes in follow-up, occurring between 2 and 146 months after radiotherapy. The 5-year actuarial rate of stroke was 12%, which corresponded to a relative risk of 2.09 ( P=.0007) compared with the population-based "expected" data. Median radiation therapy dose was 64 Gy; there was no correlation between radiation therapy dose and stroke risk. No correlation was identified between surgery near the carotids and stroke risk.
conclusionsAn association between high-dose cervical irradiation for squamous cell carcinoma of the head and neck and stroke is demonstrated. Although the relative risk is approximately doubled, the absolute risk is modest in comparison to the risk of cancer recurrence. Further study of this association and possible interventions is warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.