ArticleProceedings of the National Academy of Sciences of the United States of America2002
Electrical cues regulate the orientation and frequency of cell division and the rate of wound healing in vivo.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
95 citing papers in PubMed, 240 citations in OpenAlex.
- Molecular Mechanisms of Electric Signals Generated at Corneal Wounds.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Bioelectric Reawakening by a Self-Powered Thermoelectric Hydrogel Accelerates Diabetic Ulcer Repair.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Wearable Battery-Free Electrotherapy of Smartsensors for Wound Healthcare.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- EMERGE patch, a novel electrogenic engineered material to enhance healing of severe corneal wounds.Biomaterials · 2026Article
- Conductive Microneedles Loaded With Polyphenol-Engineered Exosomes Reshape Diabetic Neurovascular Niches for Chronic Wound Healing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Interactions Between Active Matters and Endogenous Fields.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Electrical Stimulation Therapy - Dedicated to the Perfect Plastic Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- A Bioelectrically Enabled Smart Bandage for Accelerated Wound Healing and Predictive Monitoring.Medicina (Kaunas, Lithuania) · 2025Article
- Electrical Forces in Biology Across Distances.Reviews of physiology, biochemistry and pharmacology · 2025Review
- Making Proteins with Electricity.Reviews of physiology, biochemistry and pharmacology · 2025Review
- A quadriphasic mechanical model of the human dermis.Biomechanics and modeling in mechanobiology · 2024Article
- Conductive gradient hydrogels allow spatial control of adult stem cell fate.Journal of materials chemistry. B · 2024Article
- Review
- Bioelectricity in dental medicine: a narrative review.Biomedical engineering online · 2024Review
- Synthesis, Properties, and Applications of Nanocomposite Materials Based on Bacterial Cellulose and MXene.Polymers · 2023Review
- Biodegradable piezoelectric skin-wound scaffold.Biomaterials · 2023Article
- Reducing Sialylation Enhances Electrotaxis of Corneal Epithelial Cells.International journal of molecular sciences · 2023Article
- Snowflake-inspired and blink-driven flexible piezoelectric contact lenses for effective corneal injury repair.Nature communications · 2023Article
- Inflammation Responses to Bone Scaffolds under Mechanical Stimuli in Bone Regeneration.Journal of functional biomaterials · 2023Review
- Current progress and trends in musculoskeletal research: Highlights of NSFC-CUHK academic symposium on bone and joint degeneration and regeneration.Journal of orthopaedic translation · 2022Review
35 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Controlling cell division is fundamental. One environmental cue that exerts profound control over both the orientation and frequency of cell division in vivo is a naturally occurring, wound-induced electric field (EF). Wounds in rat corneas generate endogenous EFs in the plane of the epithelial sheet because the transcorneal potential difference (TCPD; +40 mV internally positive) collapses at the wound edge, but is maintained at normal levels at 0.5 mm back from the wound. We manipulated the endogenous EF this creates by using drugs with differing actions. The wound-induced EF controlled the orientation of cell division; most epithelial cells divided with a cleavage plane parallel to the wound edge and perpendicular to the EF vector. Increasing or decreasing the EF pharmacologically, respectively increased or decreased the extent of oriented cell division. In addition, cells closest to the wound edge, where the EF was highest, were oriented most strongly by the EF. Remarkably, an endogenous EF also enhanced the frequency of cell division. This also was regulated by enhancing or suppressing the EF pharmacologically. Because the endogenous EF also regulated the wound healing rate, it may act as one control of the interplay between cell migration and cell division during healing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.