ArticleProceedings of the National Academy of Sciences of the United States of America2002
Existing antivirals are effective against influenza viruses with genes from the 1918 pandemic virus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed.
- The host tropism of current zoonotic H7N9 viruses depends mainly on an acid-labile hemagglutinin with a single amino acid mutation in the stalk region.PLoS pathogens · 2024Article
- Which Virus Will Cause the Next Pandemic?Viruses · 2023Article
- In Vitro and In Vivo Antiviral Studies of New Heteroannulated 1,2,3-Triazole Glycosides Targeting the Neuraminidase of Influenza A Viruses.Pharmaceuticals (Basel, Switzerland) · 2022Article
- COVID-19: Antiviral agents and enzyme inhibitors/receptor blockers in development.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- Problems associated with antiviral drugs and vaccines development for COVID-19: approach to intervention using expression vectors via GPI anchor.Nucleosides, nucleotides & nucleic acids · 2021Review
- The 1918 Influenza Pandemic and Its Legacy.Cold Spring Harbor perspectives in medicine · 2020Review
- The Rationale for Potential Pharmacotherapy of COVID-19.Pharmaceuticals (Basel, Switzerland) · 2020Review
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- The 1918 influenza pandemic: 100 years of questions answered and unanswered.Science translational medicine · 2019Review
- Review
- Multiple polymerase gene mutations for human adaptation occurring in Asian H5N1 influenza virus clinical isolates.Scientific reports · 2018Article
- Avian Influenza Virus Infection of Immortalized Human Respiratory Epithelial Cells Depends upon a Delicate Balance between Hemagglutinin Acid Stability and Endosomal pH.The Journal of biological chemistry · 2015Article
- Circulating avian influenza viruses closely related to the 1918 virus have pandemic potential.Cell host & microbe · 2014Article
- The impact of viral genotype on pathogenesis and disease severity: respiratory syncytial virus and human rhinoviruses.Current opinion in immunology · 2013Review
- Oseltamivir inhibits H7 influenza virus replication in mice inoculated by the ocular route.Antimicrobial agents and chemotherapy · 2012Article
- Developments in antivirals against influenza, smallpox and hemorrhagic fever viruses.Expert opinion on investigational drugs · 2011Review
- Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Analysis of in vivo dynamics of influenza virus infection in mice using a GFP reporter virus.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The 1918 influenza pandemic caused more than 20 million deaths worldwide. Thus, the potential impact of a re-emergent 1918 or 1918-like influenza virus, whether through natural means or as a result of bioterrorism, is of significant concern. The genetic determinants of the virulence of the 1918 virus have not been defined yet, nor have specific clinical prophylaxis and/or treatment interventions that would be effective against a re-emergent 1918 or 1918-like virus been identified. Based on the reported nucleotide sequences, we have reconstructed the hemagglutinin (HA), neuraminidase (NA), and matrix (M) genes of the 1918 virus. Under biosafety level 3 (agricultural) conditions, we have generated recombinant influenza viruses bearing the 1918 HA, NA, or M segments. Strikingly, recombinant viruses possessing both the 1918 HA and 1918 NA were virulent in mice. In contrast, a control virus with the HA and NA from a more recent human isolate was unable to kill mice at any dose tested. The recombinant viruses were also tested for their sensitivity to U.S. Food and Drug Administration-approved antiinfluenza virus drugs in vitro and in vivo. Recombinant viruses possessing the 1918 NA or both the 1918 HA and 1918 NA were inhibited effectively in both tissue culture and mice by the NA inhibitors, zanamivir and oseltamivir. A recombinant virus possessing the 1918 M segment was inhibited effectively both in tissue culture and in vivo by the M2 ion-channel inhibitors amantadine and rimantadine. These data suggest that current antiviral strategies would be effective in curbing the dangers of a re-emergent 1918 or 1918-like virus.
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