ArticleJournal of virology2002
Characterization of Moloney murine leukemia virus p12 mutants blocked during early events of infection.
Article in Journal of virology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Brief Histories of Retroviral Integration Research and Associated International Conferences.Viruses · 2024Review
- BET-Independent Murine Leukemia Virus Integration Is RetargetedMicrobiology spectrum · 2022Article
- Silencing of Unintegrated Retroviral DNAs.Viruses · 2021Review
- Moloney Murine Leukemia Virus p12 Is Required for Histone Loading onto Retroviral DNAs.Journal of virology · 2021Article
- The N-terminus of murine leukaemia virus p12 protein is required for mature core stability.PLoS pathogens · 2014Article
- p12 tethers the murine leukemia virus pre-integration complex to mitotic chromosomes.PLoS pathogens · 2012Article
- The gammaretroviral p12 protein has multiple domains that function during the early stages of replication.Retrovirology · 2012Article
- Murine leukemia viruses: objects and organisms.Advances in virology · 2011Article
- The Gag cleavage product, p12, is a functional constituent of the murine leukemia virus pre-integration complex.PLoS pathogens · 2010Article
- Article
- Capsid is an important determinant for functional complementation of murine leukemia virus and spleen necrosis virus Gag proteins.Virology · 2007Article
- Mutation in the glycosylated gag protein of murine leukemia virus results in reduced in vivo infectivity and a novel defect in viral budding or release.Journal of virology · 2007Article
- HIV infection of non-dividing cells: a divisive problem.Retrovirology · 2006Article
- High-throughput, library-based selection of a murine leukemia virus variant to infect nondividing cells.Journal of virology · 2006Article
- A phenotypic recessive, post-entry block in rabbit cells that results in aberrant trafficking of HIV-1.Traffic (Copenhagen, Denmark) · 2006Article
- Parallels among positive-strand RNA viruses, reverse-transcribing viruses and double-stranded RNA viruses.Nature reviews. Microbiology · 2006Review
- Interaction of moloney murine leukemia virus capsid with Ubc9 and PIASy mediates SUMO-1 addition required early in infection.Journal of virology · 2006Article
- The cell cycle independence of HIV infections is not determined by known karyophilic viral elements.PLoS pathogens · 2005Article
- Cooperative effect of gag proteins p12 and capsid during early events of murine leukemia virus replication.Journal of virology · 2005Article
- Early detection of a two-long-terminal-repeat junction molecule in the cytoplasm of recombinant murine leukemia virus-infected cells.Journal of virology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Mutations affecting either the N- or C-terminal regions of the Gag protein p12 block replication of Moloney murine leukemia virus (M-MuLV). Viruses carrying mutations in this portion of gag can mediate the assembly and release of virions but are unable to successfully carry out the early phase of the M-MuLV life cycle. Wild-type and mutant viruses were found to synthesize similar levels of linear viral DNA in both cytoplasmic and nuclear fractions, and there were no significant differences in either the density or sedimentation of the viral protein-nucleic acid complexes. Analysis of the termini of the linear viral DNAs showed that the 3' ends of the mutant viral DNA were processed normally by the integrase. Further, the preintegration complexes extracted from the cytoplasm of cells infected with the mutant viruses were competent for integration into target DNA in vitro. Nevertheless, no circular viral DNAs were detected in cells infected by the mutants, and functional proviruses were not formed. These results suggest that p12 has an unexpected role in the early phase of the life cycle and is needed after viral DNA synthesis to deliver the incoming DNA to the correct location and in the appropriate state to permit either circularization or integration of the viral DNA in vivo.
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