ArticleThe American journal of pathology2002
Virus-induced demyelination in nude mice is mediated by gamma delta T cells.
Article in The American journal of pathology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 51 citations in OpenAlex.
- Remyelination in animal models of multiple sclerosis: finding the elusive grail of regeneration.Frontiers in molecular neuroscience · 2023Review
- A Review on SARS-CoV-2-Induced Neuroinflammation, Neurodevelopmental Complications, and Recent Updates on the Vaccine Development.Molecular neurobiology · 2021Review
- Elucidating the Neuropathologic Mechanisms of SARS-CoV-2 Infection.Frontiers in neurology · 2021Review
- Single-Cell RNA Sequencing Reveals the Diversity of the Immunological Landscape following Central Nervous System Infection by a Murine Coronavirus.Journal of virology · 2020Article
- Innate, innate-like and adaptive lymphocytes in the pathogenesis of MS and EAE.Cellular & molecular immunology · 2019Review
- Transplanted human thymus slices induce and support T-cell development in mice after cryopreservation.European journal of immunology · 2018Article
- Regenerative potential of tonsil mesenchymal stem cells on surgical cutaneous defect.Cell death & disease · 2018Article
- Multiple sclerosis: experimental models and reality.Acta neuropathologica · 2017Review
- The Emerging Roles of Gamma-Delta T Cells in Tissue Inflammation in Experimental Autoimmune Encephalomyelitis.Frontiers in immunology · 2016Review
- Role of γδ T cells in antibody production and recovery from SFV demyelinating disease.Journal of neuroimmunology · 2011Article
- Article
- gammadelta T cells: the overlooked T-cell subset in demyelinating disease.Journal of neuroscience research · 2010Review
- A mechanism of virus-induced demyelination.Interdisciplinary perspectives on infectious diseases · 2010Article
- Vaccines for Venezuelan equine encephalitis.Vaccine · 2009Review
- Interleukin-12 (IL-12), but not IL-23, deficiency ameliorates viral encephalitis without affecting viral control.Journal of virology · 2009Article
- Murine coronavirus-induced oligodendrocyte apoptosis is mediated through the activation of the Fas signaling pathway.Virology · 2007Article
- Pathogenesis of acute and chronic central nervous system infection with variants of mouse hepatitis virus, strain JHM.Immunologic research · 2007Review
- Mouse hepatitis virus pathogenesis in the central nervous system is independent of IL-15 and natural killer cells.Virology · 2006Article
- Anti-severe acute respiratory syndrome coronavirus immune responses: the role played by V gamma 9V delta 2 T cells.The Journal of infectious diseases · 2006Article
- Role of the mitochondrial signaling pathway in murine coronavirus-induced oligodendrocyte apoptosis.Journal of virology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Infection of mice with mouse hepatitis virus (MHV), strain JHM, results in acute and chronic demyelination with many similarities to the human disease multiple sclerosis. This pathological process is primarily T cell-mediated and MHV infection of mice lacking B and T cells does not result in demyelination. In apparent contradiction to these results, robust demyelination is detected in MHV-infected young nude (athymic) mice. Herein, we show that demyelination in nude mice was mediated by gamma delta T cells. These cells, but not conventional CD4 or CD8 alpha beta T cells, were detected in the central nervous system of MHV-infected nude mice and their depletion with neutralizing antibody resulted in an 80% reduction in demyelination. These results show, for the first time, that gamma delta T cells can substitute for alpha beta T cells in a virus model of demyelination and further support a pathological role for gamma delta T cells in patients with multiple sclerosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.