ArticleThe American journal of pathology2002
Distinct and complementary information provided by use of tissue and DNA microarrays in the study of breast tumor markers.
Article in The American journal of pathology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
53 citing papers in PubMed, 142 citations in OpenAlex.
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- Protein expression profiles and clinicopathologic characteristics associate with gastric cancer survival.Biological research · 2019Article
- Integrated analysis highlights APC11 protein expression as a likely new independent predictive marker for colorectal cancer.Scientific reports · 2018Article
- Stromal Expression of MARCKS Protein in Ovarian Carcinomas Has Unfavorable Prognostic Value.International journal of molecular sciences · 2017Article
- Aldehyde dehydrogenase 1 (ALDH1) expression is an independent prognostic factor in triple negative breast cancer (TNBC).Medicine · 2017Observational
- MARCKS protein overexpression in inflammatory breast cancer.Oncotarget · 2017Article
- Inverse association of rab31 and mucin-1 (CA15-3) antigen levels in estrogen receptor-positive (ER+) breast cancer tissues with clinicopathological parameters and patients' prognosis.American journal of cancer research · 2017Article
- Prognostic significance of mucin expression profiles in breast carcinoma with signet ring cells: a clinicopathological study.Diagnostic pathology · 2016Article
- AECHL-1, a novel triterpenoid, targets tumor neo-vasculature and impairs the endothelial cell cytoskeleton.Angiogenesis · 2015Article
- Overexpression of the Promigratory and Prometastatic PTK7 Receptor Is Associated with an Adverse Clinical Outcome in Colorectal Cancer.PloS one · 2015Article
- Using immunoproteomics to identify tumor-associated antigens (TAAs) as biomarkers in cancer immunodiagnosis.Autoimmunity reviews · 2013Review
- ARID1B, a member of the human SWI/SNF chromatin remodeling complex, exhibits tumour-suppressor activities in pancreatic cancer cell lines.British journal of cancer · 2013Article
- Gene expression profiling of solitary fibrous tumors.PloS one · 2013Article
- Glycoprotein profiles of human breast cells demonstrate a clear clustering of normal/benign versus malignant cell lines and basal versus luminal cell lines.Journal of proteome research · 2012Article
- Molecular and epidemiological characteristics of inflammatory breast cancer in Algerian patients.Breast cancer research and treatment · 2012Article
- High levels of the Mps1 checkpoint protein are protective of aneuploidy in breast cancer cells.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Genome profiling of ERBB2-amplified breast cancers.BMC cancer · 2010Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Emerging high-throughput screening technologies are rapidly providing opportunities to identify new diagnostic and prognostic markers and new therapeutic targets in human cancer. Currently, cDNA arrays allow the quantitative measurement of thousands of mRNA expression levels simultaneously. Validation of this tool in hospital settings can be done on large series of archival paraffin-embedded tumor samples using the new technique of tissue microarray. On a series of 55 clinically and pathologically homogeneous breast tumors, we compared for 15 molecules with a proven or suspected role in breast cancer, the mRNA expression levels measured by cDNA array analysis with protein expression levels obtained using tumor tissue microarrays. The validity of cDNA array and tissue microarray data were first verified by comparison with quantitative reverse transcriptase-polymerase chain reaction measurements and immunohistochemistry on full tissue sections, respectively. We found a good correlation between cDNA and tissue array analyses in one-third of the 15 molecules, and no correlation in the remaining two-thirds. Furthermore, protein but not RNA levels may have prognostic value; this was the case for MUC1 protein, which was studied further using a tissue microarray containing approximately 600 tumor samples. For THBS1 the opposite was observed because only RNA levels had prognostic value. Thus, differences extended to clinical prognostic information obtained by the two methods underlining their complementarity and the need for a global molecular analysis of tumors at both the RNA and protein levels.
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