ArticleThe American journal of pathology2002
Heterogeneity of ductular reactions in adult rat and human liver revealed by novel expression of deleted in malignant brain tumor 1.
Article in The American journal of pathology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 68 citations in OpenAlex.
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- The diversity and plasticity of adult hepatic progenitor cells and their niche.Liver international : official journal of the International Association for the Study of the Liver · 2017Review
- Increased expression of deleted in malignant brain tumors (DMBT1) gene in precancerous gastric lesions: Findings from human and animal studies.Oncotarget · 2017Article
- RNA-Seq reveals common and unique PXR- and CAR-target gene signatures in the mouse liver transcriptome.Biochimica et biophysica acta · 2016Article
- miR-133b Regulation of Connective Tissue Growth Factor: A Novel Mechanism in Liver Pathology.The American journal of pathology · 2016Article
- Essential amino acid transporter Lat4 (Slc43a2) is required for mouse development.The Journal of physiology · 2015Article
- Two-tier regenerative response in liver failure in humans.Virchows Archiv : an international journal of pathology · 2014Article
- The origin, biology, and therapeutic potential of facultative adult hepatic progenitor cells.Current topics in developmental biology · 2014Review
- Dmbt1 does not affect a Western style diet-induced liver damage in mice.Journal of clinical biochemistry and nutrition · 2013Article
- Article
- RNA-Seq profiling reveals novel hepatic gene expression pattern in aflatoxin B1 treated rats.PloS one · 2013Article
- The role of stem cells in liver repair and fibrosis.The international journal of biochemistry & cell biology · 2011Review
- Global gene expression profiling reveals a key role of CD44 in hepatic oval-cell reaction after 2-AAF/CCl4 injury in rodents.Histochemistry and cell biology · 2009Article
- Developmental pathways during in vitro progression of human islet neogenesis.Differentiation; research in biological diversity · 2009Article
- Stem cells in liver regeneration and therapy.Cell and tissue research · 2008Review
- Activation of stem cells in hepatic diseases.Cell and tissue research · 2008Review
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The regenerative capacity of mammalian adult liver reflects the ability of a number of cell populations within the hepatic lineage to take action. Limited information is available regarding factors and mechanisms that determine the specific lineage level at which liver cells contribute to liver repair as well as the fate of their progeny in the hostile environment created by liver injury. In the present study, we attempted to identify novel molecules preferentially involved in liver regeneration by recruitment of transit-amplifying, ductular (oval) cell populations. With a subtractive cDNA library screening approach, we identified 48 enriched, nonredundant gene products associated with liver injury and oval cell proliferation in the adult rat liver. Of these, only two, namely alpha-fetoprotein and a novel transcript with high homology to human DMBT1 (deleted in malignant brain tumor 1), were specifically associated with the emergence of ductular (oval) cell populations in injured liver. Subsequent cloning and characterization of the rat DMBT1 homologue revealed a highly inducible expression in ductular reactions composed of transit-amplifying ductular (oval) cells, but not in ductular reactions after ligation of the common bile duct. In human liver diseases, DMBT1 was expressed in ductular reactions after infection with hepatitis B and acetaminophen intoxication, but not in primary biliary cirrhosis, primary sclerosing cholangitis, and obstruction of the large bile duct. The expression heterogeneity in ductular reactions and multiple functions of DMBT1 homologues point to intriguing roles in regulating not only tissue repair but also fate decision and differentiation paths of specific cell populations in the hepatic lineage.
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