Trial reportBMC neuroscience2002
Assessing the molecular genetics of attention networks.
Trial report in BMC neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
119 citing papers in PubMed, 1 synthesis or guideline pooled it, 341 citations in OpenAlex.
- Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls.Molecular psychiatry · 2007Pooled it
- Healthy or not? The impact of conflicting health-related information on attentional resources.Journal of behavioral medicine · 2022Trial
- The Positive Modulation Effect of a 6-Week Consumption of an Anthocyanin-Rich Mulberry Milk on Working Memory, Cholinergic, and Monoaminergic Functions in Healthy Working-Age Adults.Oxidative medicine and cellular longevity · 2021Trial
- DRD2 and DRD4 genes related to cognitive deficits in HIV-infected adults who abuse alcohol.Behavioral and brain functions : BBF · 2015Trial
- Dopamine genes (DRD2/ANKK1-TaqA1 and DRD4-7R) and executive function: their interaction with obesity.PloS one · 2012Trial
- Differential effects of DRD4 and DAT1 genotype on fronto-striatal gray matter volumes in a sample of subjects with attention deficit hyperactivity disorder, their unaffected siblings, and controls.Molecular psychiatry · 2005Trial
- Characterizing the functioning of the attentional networks in state and trait anxiety: the role of affective information.Frontiers in psychology · 2025Article
- Genetics and Traumatic Brain Injury: Findings from an Exome-Based Study of a 50-Patient Case Series.Current issues in molecular biology · 2024Article
- Molecular signatures of attention networks.Human brain mapping · 2024Article
- TTLL11 gene is associated with sustained attention performance and brain networks: A genome-wide association study of a healthy Chinese sample.Genes, brain, and behavior · 2023Article
- Article
- The role of alerting in the attentional boost effect.Frontiers in psychology · 2023Article
- Attention networks and the intrinsic network structure of the human brain.Human brain mapping · 2022Article
- Evidence that ageing yields improvements as well as declines across attention and executive functions.Nature human behaviour · 2022Article
- Correlation research of susceptibility single nucleotide polymorphisms and the severity of clinical symptoms in attention deficit hyperactivity disorder.Frontiers in psychiatry · 2022Article
- Imaging Genetic Based Mediation Analysis for Human Cognition.Frontiers in neuroscience · 2022Article
- Gender Differences in Attention Adaptation after an 8-Week FIFA 11Children (Basel, Switzerland) · 2021Article
- Autistic traits are associated with the functional connectivity of between-but not within-attention systems in the general population.BMC neuroscience · 2020Article
- Decreased Alertness Reconfigures Cognitive Control Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- The SLC6A3 gene polymorphism is related to the development of attentional functions but not to ADHD.Scientific reports · 2020Observational
59 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCurrent efforts to study the genetic underpinnings of higher brain functions have been lacking appropriate phenotypes to describe cognition. One of the problems is that many cognitive concepts for which there is a single word (e.g. attention) have been shown to be related to several anatomical networks. Recently, we have developed an Attention Network Test (ANT) that provides a separate measure for each of three anatomically defined attention networks.
resultsIn this study we have measured the efficiency of neural networks related to aspects of attention using the ANT in a population of 200 adult subjects. We then examined genetic polymorphisms in four candidate genes (DRD4, DAT, COMT and MAOA) that have been shown to contribute to the risk of developing various psychiatric disorders where attention is disrupted. We find modest associations of several polymorphisms with the efficiency of executive attention but not with overall performance measures such as reaction time.
conclusionsThese results suggest that genetic variation may underlie inter-subject variation in the efficiency of executive attention. This study also shows that genetic influences on executive attention may be specific to certain anatomical networks rather than affecting performance in a global or non-specific manner. Lastly, this study further validates the ANT as an endophenotypic assay suitable for assessing how genes influence certain anatomical networks that may be disrupted in various psychiatric disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.