ArticleThe Histochemical journal
Expression of cell adhesion molecules, their ligands and tumour necrosis factor alpha in the liver of patients with metastatic gastrointestinal carcinomas.
Article in The Histochemical journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- Identification of differentially expressed genes and biological pathways in para-carcinoma tissues of HCC with different metastatic potentials.Oncology letters · 2020Article
- IL-6 Activities in the Tumour Microenvironment. Part 1.Open access Macedonian journal of medical sciences · 2019Review
- Role of liver ICAM-1 in metastasis.Oncology letters · 2017Article
- The p38 pathway, a major pleiotropic cascade that transduces stress and metastatic signals in endothelial cells.Oncotarget · 2017Review
- Prognostic value of β1 integrin expression in colorectal liver metastases.International journal of clinical and experimental pathology · 2014Article
- CXC chemokine ligand 12/stromal cell-derived factor-1 regulates cell adhesion in human colon cancer cells by induction of intercellular adhesion molecule-1.Journal of biomedical science · 2012Article
- LFA-1 and ICAM-1 expression induced during melanoma-endothelial cell co-culture favors the transendothelial migration of melanoma cell lines in vitro.BMC cancer · 2012Article
- EpCAM: a potential antimetastatic target for gastric cancer.Digestive diseases and sciences · 2010Article
- EpCAM is overexpressed in gastric cancer and its downregulation suppresses proliferation of gastric cancer.Journal of cancer research and clinical oncology · 2009Article
- L-selectin-mediated lymphocyte-cancer cell interactions under low fluid shear conditions.The Journal of biological chemistry · 2008Article
- Integrins as antimetastatic targets of RGD-independent snake venom components in liver metastasis [corrected].Neoplasia (New York, N.Y.) · 2008Article
- Stromal fibroblasts in colorectal liver metastases originate from resident fibroblasts and generate an inflammatory microenvironment.The American journal of pathology · 2007Article
- Adhesion molecules in chronic ulcerative colitis.International journal of colorectal disease · 2007Article
- The host inflammatory response promotes liver metastasis by increasing tumor cell arrest and extravasation.The American journal of pathology · 2007Article
- Expression of beta2-integrin on leukocytes in liver cirrhosis.World journal of gastroenterology · 2006Article
- Liver metastasis and ICAM-1 mRNA expression in the liver after carbon dioxide pneumoperitoneum in a murine model.Surgical endoscopy · 2005Article
- Focal adhesion kinase regulates metastatic adhesion of carcinoma cells within liver sinusoids.The American journal of pathology · 2005Article
- Collagen type IV, laminin, alpha-smooth muscle actin (alphaSMA), alpha1 and alpha6 integrins expression in the liver with metastases from malignant gastrointestinal tumours.Clinical & experimental metastasis · 2004Article
- Association of VCAM-1 overexpression with oncogenesis, tumor angiogenesis and metastasis of gastric carcinoma.World journal of gastroenterology · 2003Article
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1 author at 1 institution in 1 country.
Funding
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Abstract
The expression of the following cell adhesion molecules, their beta1 and beta2 integrin ligands and the cytokine tumour necrosis factor-alpha (TNF-alpha) was investigated by light and electron microscope immunohistochemistry in the liver tissue in 20 patients with colorectal and gastric cancer also presenting with liver metastases: intercellular adhesion molecule-1 (ICAM-1), vascular endothelial adhesion molecule-1 (VCAM-1), E-selectin, leucocyte function-associated antigen-1 (LFA-1), macrophage antigen-1 (Mac-1), and very late antigen-4 (VLA-4). We have found a parallel enhancement of the adhesion molecules and of TNF-alpha in liver sinusoids surrounding metastases. The expression of ICAM-1 was enhanced on sinusoidal cells in all zones of the acinus. VCAM-1 immune reactivity was diffuse but less intensive in the lobule. E-selectin expression was observed in sinusoidal cells attached to metastases. In tumour metastases the expression of ICAM-1, VCAM-1, and E-selectin was visible on the tumour vascular endothelium. Tumour infiltrating host cells sowing positive immunoreactivity for ICAM-1, VCAM-1, LFA-1, Mac-1, and VLA-4 were located mainly at the boundary between liver parenchyma and the metastasis. At the ultrastructural level, ICAM-1-positive immune deposits were observed on the cellular membrane and in some transport vesicles of gastric metastatic cells. Further, the expression of all adhesion molecules was confirmed to sinusoidal endothelial cells and tumour vessels. It is concluded that the enhanced expression of adhesion molecules in liver sinusoids could be a marker for the assessment of the ability of sinusoidal endothelial cells to control the recruitment of leukocytes and monocytes to the metastatic site. They could also direct the adhesion of new circulating tumour cells to sinusoidal endothelium.
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