ReviewGene therapy2002
Gene therapy progress and prospects: cystic fibrosis.
Review in Gene therapy, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Progress in Respiratory Gene Therapy.Human gene therapy · 2022Review
- Beyond cystic fibrosis transmembrane conductance regulator therapy: a perspective on gene therapy and small molecule treatment for cystic fibrosis.Gene therapy · 2019Review
- Chitosan in Non-Viral Gene Delivery: Role of Structure, Characterization Methods, and Insights in Cancer and Rare Diseases Therapies.Polymers · 2018Review
- Noninvasive assessment of gene transfer and expression by in vivo functional and morphologic imaging in a rabbit tumor model.PloS one · 2013Article
- Nanoparticle deposition onto biofilms.Annals of biomedical engineering · 2013Article
- Hoechst increases adeno-associated virus-mediated transgene expression in airway epithelia by inducing the cytomegalovirus promoter.The journal of gene medicine · 2012Article
- Gene therapy for the treatment of cystic fibrosis.The application of clinical genetics · 2012Article
- Lentiviral vectors and cystic fibrosis gene therapy.Viruses · 2010Article
- In vitro and in vivo functional characterization of gutless recombinant SV40-derived CFTR vectors.Gene therapy · 2010Article
- Sensitivity of chloride efflux vs. transepithelial measurements in mixed CF and normal airway epithelial cell populations.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2010Article
- Nanomedicine for the management of lung and blood diseases.Nanomedicine (London, England) · 2009Review
- Canine adenovirus vectors for lung-directed gene transfer: efficacy, immune response, and duration of transgene expression using helper-dependent vectors.Journal of virology · 2006Article
- Airway gene transfer using cationic emulsion as a mucosal gene carrier.The journal of gene medicine · 2005Article
- Gene therapy progress and prospects: episomally maintained self-replicating systems.Gene therapy · 2004Review
- Lentivirus-mediated gene transfer to the respiratory epithelium: a promising approach to gene therapy of cystic fibrosis.Gene therapy · 2004Review
- Celiac disease: a model autoimmune disease with gene therapy applications.Gene therapy · 2003Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since the cloning of the cystic fibrosis gene (CFTR) in 1989, 18 clinical trials have been carried out, including five in the 2 years reviewed here. Most trials demonstrated proof-of-principle for gene transfer to the airway. However, gene transfer efficiency with each of the three gene transfer agents (adenovirus (Ad), adeno-associated virus 2 (AAV2) and cationic liposomes) was low, and most likely insufficient to achieve clinical benefit. Here, we will review the clinical and pre-clinical progress for the last 2 years (2000-2001) and briefly speculate on future prospects for the next 2 in CF gene therapy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.