ReviewOncogene2002
Functional cloning of a tumor suppressor gene, TSLC1, in human non-small cell lung cancer.
Review in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 64 citations in OpenAlex.
- Molecular cloning, characterization, and functional analysis of the uncharacterized C11orf96 gene.BMC veterinary research · 2022Article
- CADM1 associates with Hippo pathway core kinases; membranous co-expression of CADM1 and LATS2 in lung tumors predicts good prognosis.Cancer science · 2019Article
- Expression profile of CADM1 and CADM4 in triple negative breast cancer with primary systemic therapy.Oncology letters · 2019Article
- Epithelial-mesenchymal transition leads to NK cell-mediated metastasis-specific immunosurveillance in lung cancer.The Journal of clinical investigation · 2018Article
- Decreased expression of CADM1 and CADM4 are associated with advanced stage breast cancer.Oncology letters · 2018Article
- An innovative strategy to clone positive modifier genes of defects caused by mtDNA mutations: MRPS18C as suppressor gene of m.3946G>A mutation in MT-ND1 gene.Human genetics · 2017Article
- Folate deficiency and aberrant expression of cell adhesion molecule 1 are potential indicators of prognosis in laryngeal squamous cell carcinoma.Oncology letters · 2016Article
- MYCN-mediated miR-21 overexpression enhances chemo-resistance via targeting CADM1 in tongue cancer.Journal of molecular medicine (Berlin, Germany) · 2016Article
- Loss of CADM1/TSLC1 Expression Is Associated with Poor Clinical Outcome in Patients with Esophageal Squamous Cell Carcinoma.Gastroenterology research and practice · 2016Article
- Loss of heterozygosity: what is it good for?BMC medical genomics · 2015Article
- MicroRNA-1246 enhances migration and invasion through CADM1 in hepatocellular carcinoma.BMC cancer · 2014Article
- Expression of a splicing variant of the CADM1 specific to small cell lung cancer.Cancer science · 2012Article
- Re-expression of cell adhesion molecule inhibits growth and induces apoptosis of human pancreatic cancer cell line PANC-1.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2011Article
- [Expressions and clinical significances of TSLC1 and 4.1B in non-small cell lung cancer].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2010Article
- Silencing of ErbB3/ErbB2 signaling by immunoglobulin-like Necl-2.The Journal of biological chemistry · 2009Article
- Expression and DNA methylation patterns of Tslc1 and Dal-1 genes in hepatocellular carcinomas induced by N-nitrosodiethylamine in rats.Cancer science · 2007Article
- Cell adhesion and prostate tumor-suppressor activity of TSLL2/IGSF4C, an immunoglobulin superfamily molecule homologous to TSLC1/IGSF4.Oncogene · 2006Article
- Involvement of a cell adhesion molecule, TSLC1/IGSF4, in human oncogenesis.Cancer science · 2005Review
- Loss of TSLC1 expression in lung adenocarcinoma: relationships with histological subtypes, sex and prognostic significance.Cancer science · 2005Article
- Article
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1 author at 1 institution in 1 country.
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Abstract
The identification of a tumor suppressor gene in non-small cell lung cancer (NSCLC) is one of the most important issues to elucidate the molecular mechanisms of this type of refractory cancer and to establish a novel strategy against it. Since NSCLC, like most other human cancers, develops as a sporadic disease, linkage analysis is not available for gene cloning. This review describes the functional cloning approaches to a tumor suppressor gene in sporadic cancers. Suppression of the malignant phenotype of cancer cells by fusion with a normal fibroblast was the first demonstration of the recessive phenotype of cancer cells in 1969. Evidence of tumor suppressor genes on the specific chromosomes was later provided by functional complementation of the cancer phenotype through microcell-mediated chromosome transfer. Further introduction of more restricted DNA fragments by YAC transfer provides a potent tool to localize the gene to a small segment, appropriate for the subsequent gene cloning. TSLC1, a novel tumor suppressor gene in NSCLC, was identified on chromosome 11q23.2 through a series of functional complementation of A549 cells in tumorigenicity. Two-hit inactivation of the TSLC1 by promoter methylation and gene deletion was observed in 40% of primary NSCLC tumors. The strong tumor suppressor activity of TSLC1, and its possible involvement in cell adhesion, suggest that the functional cloning approach could cast a new light on a group of genes that have not yet been characterized, but are important for general human carcinogenesis as well as tumor suppression.
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