ArticleEnvironmental health perspectives2002
The relationship between blood lead levels and periodontal bone loss in the United States, 1988-1994.
Article in Environmental health perspectives, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 34 citations in OpenAlex.
- Effect of blood lead levels on periodontitis in American adults: a cross-sectional analysis from the national health and nutrition examination survey.BMC oral health · 2024Article
- Association between blood lead and periodontitis among American adults: a cross-sectional study of the national health and nutrition examination survey.Frontiers in pharmacology · 2024Article
- Lead exposure may affect gingival health in children.BMC oral health · 2018Article
- A discussion about public health, lead and Legionella pneumophila in drinking water supplies in the United States.The Science of the total environment · 2017Review
- Gene-environment interactions between JAZF1 and occupational and household lead exposure in prostate cancer among African American men.Cancer causes & control : CCC · 2014Article
- Association between blood lead and mercury levels and periodontitis in the Korean general population: analysis of the 2008-2009 Korean National Health and Nutrition Examination Survey data.International archives of occupational and environmental health · 2013Article
- Indices for measuring periodontitis: a literature review.International dental journal · 2011Review
- Periodontal disease and environmental cadmium exposure.Environmental health perspectives · 2009Article
- Bone lead and endogenous exposure in an environmentally exposed elderly population: the normative aging study.Journal of occupational and environmental medicine · 2009Article
- Association of environmental cadmium exposure with periodontal disease in U.S. adults.Environmental health perspectives · 2009Article
- Associations of serum concentrations of persistent organic pollutants with the prevalence of periodontal disease and subpopulations of white blood cells.Environmental health perspectives · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An association between bone disease and bone lead has been reported. Studies have suggested that lead stored in bone may adversely affect bone mineral metabolism and blood lead (PbB) levels. However, the relationship between PbB levels and bone loss attributed to periodontal disease has never been reported. In this study we examined the relationship between clinical parameters that characterize bone loss due to periodontal disease and PbB levels in the U.S. population. We used data from the Third National Health and Nutritional Examination Survey (NHANES III), 1988-1994, for the analyses. A total of 10,033 participants 20-69 years of age who completed a periodontal examination and had whole blood tested for lead were examined. Four types of periodontal disease measures were used to indicate oral bone loss: periodontal pocket depth, attachment loss extent, attachment loss severity, and the presence of dental furcations. We found that dental furcations were the best periodontal bone loss indicator for PbB levels (p = 0.005) in a multivariate linear regression model adjusting for sex, age, race/ethnicity, educational attainment, poverty status, smoking, and age of home. Furthermore, after additional modeling, we found a smoking and dental furcation interaction (p = 0.034). Subsequent stratified analyses indicated that current and past smoking is an effect modifier for dental furcations on PbB levels. These findings indicate that increased PbB levels may be associated with advanced periodontal bone loss, particularly among people with a history of smoking.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.