ArticleOncogene2002
Hp95 promotes anoikis and inhibits tumorigenicity of HeLa cells.
Article in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
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- ALIX- and ESCRT-III-dependent sorting of tetraspanins to exosomes.The Journal of cell biology · 2020Article
- Cellogram: On-the-Fly Traction Force Microscopy.Nano letters · 2019Article
- Association between Programmed Cell Death 6 Interacting Protein Insertion/Deletion Polymorphism and the Risk of Breast Cancer in a Sample of Iranian Population.Disease markers · 2015Article
- βTrCP controls the lysosome-mediated degradation of CDK1, whose accumulation correlates with tumor malignancy.Oncotarget · 2014Article
- Article
- Variations in the PDCD6 gene are associated with increased uterine leiomyoma risk in the Chinese.Genetic testing and molecular biomarkers · 2013Article
- Programmed cell death 6, a novel p53-responsive gene, targets to the nucleus in the apoptotic response to DNA damage.Cancer science · 2012Article
- The Phe105 loop of Alix Bro1 domain plays a key role in HIV-1 release.Structure (London, England : 1993) · 2011Article
- The helicase protein DHX29 promotes translation initiation, cell proliferation, and tumorigenesis.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Migfilin interacts with Src and contributes to cell-matrix adhesion-mediated survival signaling.The Journal of biological chemistry · 2009Article
- Cortactin branches out: roles in regulating protrusive actin dynamics.Cell motility and the cytoskeleton · 2008Review
- Extracellular Alix regulates integrin-mediated cell adhesions and extracellular matrix assembly.The EMBO journal · 2008Article
- The apoptosis linked gene ALG-2 is dysregulated in tumors of various origin and contributes to cancer cell viability.Molecular oncology · 2008Article
- Alternative polyadenylation produces two major transcripts of Alix.Archives of biochemistry and biophysics · 2007Article
- Amplification patterns of three genomic regions predict distant recurrence in breast carcinoma.The Journal of molecular diagnostics : JMD · 2007Article
- Src phosphorylation of Alix/AIP1 modulates its interaction with binding partners and antagonizes its activities.The Journal of biological chemistry · 2005Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
p95 is a putative signal transduction protein of approximately 95 kDa that contains multiple tyrosine residues that are conserved from yeast to human, a Src phosphorylation consensus sequence and a proline-rich C-terminus that binds SH3-domains. Previous studies have established that mammalian p95 is physically associated with proteins that regulate apoptotic induction and cell transformation; however, it is unclear whether p95 is a positive or negative regulator in these processes. Moreover, a p95 partner protein has been localized at both focal adhesions and actin-cytoskeletons in rat astrocytes. However, there is no evidence that mammalian p95 has roles in regulating cell adhesion or morphology. In this study, we examined the effects of p95 on the anchorage-independent growth and tumorigenicity of malignant HeLa cells, and on the growth and morphology of non-transformed NIH3T3 cells. In HeLa cells, p95 overexpression promoted detachment-induced apoptosis (anoikis), inhibited detachment of viable cells from substratum and reduced tumorigenicity. In NIH3T3 cells, p95 overexpression promoted flat cell morphology and slowed cell proliferation, whereas p95 downregulation had opposite effects. These findings indicate that the mammalian p95 is a positive regulator in apoptotic signaling and a negative regulator in cell transformation. They also suggest that p95 has roles in regulating cell adhesion and morphology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.