ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
Indium 111 antimyosin and Tc-99m glucaric acid for noninvasive identification of oncotic and apoptotic myocardial necrosis.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 32 citations in OpenAlex.
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- Positron Emission Tomography (PET) withMolecular imaging · 2022Article
- Untiring Pursuit for Glucarate-Based Molecular Imaging Probes.Molecular imaging and biology · 2021Review
- Cell-based and cell-free biocatalysis for the production of D-glucaric acid.Biotechnology for biofuels · 2020Review
- PET Detection of Cerebral Necrosis Using an Infarct-Avid Agent 2-Deoxy-2-[Molecular imaging and biology · 2020Article
- Cardiac molecular pathways influenced by doxorubicin treatment in mice.Scientific reports · 2019Article
- (99m)Tc glucarate as a potential radiopharmaceutical agent for assessment of tumor viability: from bench to the bed side.World journal of nuclear medicine · 2012Article
- Small-animal SPECT and SPECT/CT: application in cardiovascular research.European journal of nuclear medicine and molecular imaging · 2010Review
- Evaluating the protective role of ischaemic preconditioning in rat hearts using a stationary small-animal SPECT imager and 99mTc-glucarate.Nuclear medicine communications · 2008Article
- Myocardial uptake of 99mTc-annexin-V and 111In-antimyosin-antibodies after ischemia-reperfusion in rats.European journal of nuclear medicine and molecular imaging · 2008Article
- (99m)Tc-glucarate imaging for the early detection of infarct in partially reperfused canine myocardium.European journal of nuclear medicine and molecular imaging · 2006Article
- High-resolution imaging with (99m)Tc-glucarate for assessing myocardial injury in rat heart models exposed to different durations of ischemia with reperfusion.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2004Article
- Non-invasive in vivo imaging of myocardial apoptosis and necrosis.European journal of nuclear medicine and molecular imaging · 2003Review
- Antibodies for molecular imaging in the cardiovascular system.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyReview
- Noninvasive detection of cell death: from tracking epitaphs to counting coffins.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyArticle
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNoninvasive imaging techniques would be highly desirable to differentiate oncotic from apoptotic cell death. Indium 111 antimyosin and technetium 99m glucaric acid were used to assess whether apoptotic and oncotic myocardial cell death can be differentiated. METHODS AND
resultsCultured H9C2 rat embryonic cardiocytes and CD1 rats were treated with doxorubicin to induce myocardial apoptosis. Acute myocardial oncosis was induced by heat or subcutaneous isoproterenol administration. Scanning electron microscopy, DNA laddering, TUNEL staining, In-111 antimyosin antibody, and Tc-99m glucaric acid were used to demonstrate in vitro and in vivo doxorubicin-induced apoptosis or isoproterenol-induced myocardial oncosis. Scanning electron microscopy, DNA laddering, and TUNEL staining of H9C2 cardiocytes treated with doxorubicin all showed cell death by apoptosis. Rat hearts treated with doxorubicin (10 and 20 mg/kg) were DNA ladder-positive and localized significantly greater In-111 antimyosin antibody (mean +/- SD, 0.1942 +/- 0.0150 percent injected dose per gram [%ID/g] and 0.1825 +/- 0.0238 %ID/g, respectively) than normal hearts (0.1154 +/- 0.0270 %ID/g, P <.05). No increase in myocardial Tc-99m glucaric acid activity was observed in rat hearts after 6, 12, and 24 hours of doxorubicin injection (0.0311 +/- 0.0066 %ID/g, 0.0356 +/- 0.007 %ID/g, and 0.0368 +/- 0.0047 %ID/g, respectively; control hearts, 0.0352 +/- 0.0099 %ID/g; P = not significant). Tc-99m glucaric acid uptake was significantly greater in isoproterenol-induced oncotic hearts (0.1256 +/- 0.1023 %ID/g) than in controls (P <.0001).
conclusionsTc-99m glucaric acid is avid only for the oncotic myocardium. Antimyosin, on the other hand, is positive for both oncotic and apoptotic myocardium.
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