Trial reportJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
Impact of revascularization and myocardial viability determined by nitrate-enhanced Tc-99m sestamibi and Tl-201 imaging on mortality and functional outcome in ischemic cardiomyopathy.
Trial report in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Quantity of viable myocardium required to improve survival with revascularization in patients with ischemic cardiomyopathy: A meta-analysis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2010Pooled it
- Myocardial viability and survival in ischemic left ventricular dysfunction.The New England journal of medicine · 2011Trial
- Complex CTO Revascularization in Patients with Ischemic Heart Failure and Reduced Ejection Fraction: An Illustrative Case Series.Journal of clinical medicine · 2026Article
- The Role of Multimodality Imaging (CT & MR) as a Guide to the Management of Chronic Coronary Syndromes.Journal of clinical medicine · 2024Review
- To Revascularise or Not To Revascularise, That Is the Question: the Diagnostic and Management Conundrum of Ischaemic Cardiomyopathy.Current cardiology reports · 2016Review
- Observed influence of nitroglycerine on myocardial perfusion scintigraphy in patients with multiple vessel coronary artery disease and well-developed collaterals.World journal of nuclear medicine · 2012Article
- Multimodality imaging for assessment of myocardial viability: nuclear, echocardiography, MR, and CT.Current cardiology reports · 2012Review
- Radionuclide Imaging of Viable Myocardium: Is it Underutilized?Current cardiovascular imaging reports · 2011Article
- Prognostic and therapeutic implications of myocardial viability in patients with heart failure.Current cardiology reports · 2004Review
- Pulsed wave tissue Doppler imaging for the quantification of contractile reserve in stunned, hibernating, and scarred myocardium.Heart (British Cardiac Society) · 2004Article
- Quantification of regional left ventricular function in Q wave and non-Q wave dysfunctional regions by tissue Doppler imaging in patients with ischaemic cardiomyopathy.Heart (British Cardiac Society) · 2003Article
- Role of myocardial perfusion imaging for risk stratification in suspected or known coronary artery disease.Heart (British Cardiac Society) · 2003Review
- Incremental prognostic value of cardiac single-photon emission computed tomography after nitrate administration in patients with ischemic left ventricular dysfunction.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyArticle
- Paucity of anginal symptoms and stress-induced perfusion abnormalities in ischemic cardiomyopathy.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyArticle
- Prognostic value of myocardial perfusion-gated SPECT in patients with ischemic cardiomyopathy.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyArticle
- Prognostic validation of an algorithm to convert myocardial perfusion SPECT imaging data from a 12-segment model to a 17-segment model.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyArticle
- The historical and conceptual evolution of radionuclide assessment of myocardial viability.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyReview
- Advances in positron emission tomography.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyReview
- Antianginal medications and diagnostic accuracy of myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyArticle
- First annual Mario S. Verani, MD, Memorial lecture: clinical value of myocardial perfusion imaging in coronary artery disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNitrate-enhanced perfusion imaging has been shown to detect viability in dysfunctional myocardium, but nitrate-enhanced technetium 99m sestamibi has not been compared with nitrate-enhanced thallium 201. METHODS AND
resultsFifty-six patients with ischemic cardiomyopathy and heart failure (New York Heart Association classes II-IV) were scheduled for revascularization. Through use of a matching 12-segment model, nitrate-enhanced Tl-201 and Tc-99m sestamibi uptake at rest was assessed by 2 sets of blinded investigators. All single photon emission computed tomography data sets were read separately. Additional exercise Tc-99m sestamibi single photon emission computed tomography was performed on a separate day. Myocardial viability was thought to be present when the tracer uptake score was less than 3 (normal, 0; absent, 4). Of the 56 patients scheduled to undergo revascularization, only 23 (41%) underwent the procedure and the remainder continued medical therapy. Functional assessment by rest echocardiography was performed at 21 +/- 8 months, and survival was determined at 40 +/- 18 months. The baseline clinical and hemodynamic parameters were similar in the revascularization (n = 23) and medical therapy (n = 33) groups. Perfusion scores with nitrate-enhanced Tl-201 and Tc-99m sestamibi were similar in dysfunctional segments. Stress Tc-99m sestamibi reversible defects predicted significant improvement in left ventricular function compared with those without defects (P <.01) after revascularization. Cox regression model showed that when at least 5 reversible segments were viable, revascularization produced greater improvements in New York Heart Association class, a better trend toward survival (P =.07 for Tl-201 and P =.06 for Tc-99m), and a significantly greater impact on reverse remodeling.
conclusionsMyocardial viability determined by nitrate-enhanced Tl-201 and myocardial viability determined by Tc-99m sestamibi are equivalent for predicting functional improvements, remodeling, and survival after revascularization in patients with ischemic cardiomyopathy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.