ArticleBritish journal of pharmacology2002
Anandamide is a partial agonist at native vanilloid receptors in acutely isolated mouse trigeminal sensory neurons.
Article in British journal of pharmacology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 78 citations in OpenAlex.
- Trace-n-Seq combines retrograde fluorescent tracing with sorting and single-cell sequencing of innervating peripheral neurons.Nature protocols · 2026Review
- The analgesic paracetamol metabolite AM404 acts peripherally to directly inhibit sodium channels.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Analgesic Effect of Acetaminophen: A Review of Known and Novel Mechanisms of Action.Frontiers in pharmacology · 2020Review
- Article
- The potentiating effect of calcitonin gene-related peptide on transient receptor potential vanilloid-1 activity and the electrophysiological responses of rat trigeminal neurons to nociceptive stimuli.The journal of physiological sciences : JPS · 2018Article
- Some Prospective Alternatives for Treating Pain: The Endocannabinoid System and Its Putative Receptors GPR18 and GPR55.Frontiers in pharmacology · 2018Review
- Inhibition of anandamide hydrolysis attenuates nociceptor sensitization in a murine model of chemotherapy-induced peripheral neuropathy.Journal of neurophysiology · 2015Article
- Article
- Dampened neural activity and abolition of epileptic-like activity in cortical slices by active ingredients of spices.Scientific reports · 2014Article
- Activation of CB1 inhibits NGF-induced sensitization of TRPV1 in adult mouse afferent neurons.Neuroscience · 2014Article
- CB1 cannabinoid receptor agonist prevents NGF-induced sensitization of TRPV1 in sensory neurons.Neuroscience letters · 2013Article
- Modulation of neuropathic-pain-related behaviour by the spinal endocannabinoid/endovanilloid system.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2012Review
- TRPV1 activation is not an all-or-none event: TRPV1 partial agonism/antagonism and its regulatory modulation.Current topics in medicinal chemistry · 2011Review
- International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CB₂.Pharmacological reviews · 2010Review
- Endocannabinoid signaling in neurotoxicity and neuroprotection.Neurotoxicology · 2010Article
- The transient receptor potential vanilloid-1 channel in thermoregulation: a thermosensor it is not.Pharmacological reviews · 2009Review
- Excitation of cutaneous C nociceptors by intraplantar administration of anandamide.Brain research · 2009Article
- Inhibition of human recombinant T-type calcium channels by the endocannabinoid N-arachidonoyl dopamine.British journal of pharmacology · 2009Article
- Role of ionotropic cannabinoid receptors in peripheral antinociception and antihyperalgesia.Trends in pharmacological sciences · 2009Review
- Cannabinoid modulation of cutaneous Adelta nociceptors during inflammation.Journal of neurophysiology · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The endogenous fatty acid anandamide (AEA) is a partial agonist at cannabinoid CB1 receptors and has been reported to be a full agonist at the recombinant vanilloid receptor, VR1. 2. Whole cell voltage clamp techniques were used to examine the efficacy of AEA and related analogues methanandamide and N-(4-hydroxyphenyl)-arachidonylamide (AM404) at native VR1 receptors in acutely isolated mouse trigeminal neurons. 3. Superfusion of the VR1 agonist capsaicin onto small trigeminal neurons voltage clamped at +40 mV produced outward currents in most cells, with a pEC(50) of 6.3+/-0.1 (maximum currents at 10-30 micro M). 4. AEA produced outward currents with a pEC(50) of 5.6+/-0.1. Maximal AEA currents (30-100 micro M) were 38+/-2% of the capsaicin maximum. AEA currents were blocked by the VR1 antagonist capsazepine (30 micro M), but unaffected by the CB1 antagonist SR141716A (1 micro M). 5. Methanandamide and AM404 were less potent than AEA at activating VR1. Methanandamide (100 micro M) produced currents 37+/-6% of the capsaicin maximum, the highest concentration of AM404 tested (100 micro M) produced currents that were 55+/-9% of the capsaicin maximum. 6. Capsazepine abolished the currents produced by AM404 (100 micro M) and strongly attenuated (>70%) those produced by methanandamide (100 micro M). 7. Co-superfusion of AEA (30 micro M, methanandamide (100 micro M) or AM404 (100 micro M) with capsaicin (3 micro M) resulted in a significant reduction of the capsaicin current. 8. These data indicate that AEA, methanandamide and AM404 activate native VR1 receptors, but that all three compounds are partial agonists when compared with capsaicin.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.