SynthesisBMC infectious diseases2002
Association of circulating Chlamydia pneumoniae DNA with cardiovascular disease: a systematic review.
Synthesis in BMC infectious diseases, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 86 citations in OpenAlex.
- Association of Chlamydia pneumoniae Infection With Atherosclerotic Plaque Formation.Global journal of health science · 2015Article
- Is asthma an infectious disease? New evidence.Current allergy and asthma reports · 2013Review
- Chlamydia pneumoniae infection in atherosclerotic lesion development through oxidative stress: a brief overview.International journal of molecular sciences · 2013Review
- Chlamydophila pneumoniae infection and cardiovascular disease.North American journal of medical sciences · 2013Article
- Human oral, gut, and plaque microbiota in patients with atherosclerosis.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Persistent Chlamydophila pneumoniae infection in thoracic aortic aneurysm and aortic dissection?Upsala journal of medical sciences · 2010Article
- Exacerbation of chronic inflammatory diseases by infectious agents: Fact or fiction?World journal of diabetes · 2010Article
- Temporal delay of peak T-cell immunity determines Chlamydia pneumoniae pulmonary disease in mice.Infection and immunity · 2008Article
- Absence of Chlamydia pneumoniae and signs of atherosclerotic cardiovascular disease in adolescents with systemic lupus erythematosus.Pediatric cardiology · 2008Article
- Real time PCR for detection of Chlamydophila pneumoniae in peripheral blood mononuclear cells of patients with multiple sclerosis.Journal of neurology · 2007Article
- Detection of Chlamydia in the peripheral blood cells of normal donors using in vitro culture, immunofluorescence microscopy and flow cytometry techniques.BMC infectious diseases · 2006Article
- The CD14 functional gene polymorphism -260 C>T is not involved in either the susceptibility to Chlamydia trachomatis infection or the development of tubal pathology.BMC infectious diseases · 2005Article
- Chlamydial bacteriophage: No role in acute coronary events?The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2005Article
- The failure of antibiotics to prevent heart attacks.BMJ (Clinical research ed.) · 2005Article
- Involvement of Chlamydia pneumoniae in atherosclerosis: more evidence for lack of evidence.Journal of clinical microbiology · 2005Review
- Lack of association between vascular dementia and Chlamydia pneumoniae infection: a case-control study.BMC neurology · 2004Article
- Telithromycin treatment of chronic Chlamydia pneumoniae infection in C57BL/6J mice.Antimicrobial agents and chemotherapy · 2004Article
- Comparison of quantitative and semiquantitative enzyme-linked immunosorbent assays for immunoglobulin G against Chlamydophila pneumoniae to a microimmunofluorescence test for use with patients with respiratory tract infections.Journal of clinical microbiology · 2004Article
- The Interplay of Microbiome Dysbiosis and Cardiovascular Disease.Cardiology in reviewReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChlamydia pneumoniae antigens, nucleic acids, or intact organisms have been detected in human atheroma. However, the presence of antibody does not predict subsequent cardiovascular (CV) events. We performed a systematic review to determine whether the detection of C. pneumoniae DNA in peripheral blood mononuclear cells (PBMC) was associated with CV disease.
methodsWe sought studies of C. pneumoniae DNA detection in PBMC by polymerase chain reaction (PCR) among patients with CV disease or other clinical conditions. We pooled studies in which CV patients were compared with non-diseased controls. We analyzed differences between studies by meta-regression, to determine which epidemiological and technical characteristics were associated with higher prevalence.
resultsEighteen relevant studies were identified. In nine CV studies with control subjects, the prevalence of circulating C. pneumoniae DNA was 252 of 1763 (14.3%) CV patients and 74 of 874 (8.5%) controls, for a pooled odds ratio of 2.03 (95% CI: 1.34, 3.08, P < 0.001). Prevalence was not adjusted for CV risk factors. Current smoking status, season, and age were associated with C. pneumoniae DNA detection. High prevalence (>40%) was found in patients with cardiac, vascular, chronic respiratory, or renal disease, and in blood donors. Substantial differences between studies were identified in methods of sampling, extraction, and PCR targets.
conclusionsC. pneumoniae DNA detection was associated with CV disease in unadjusted case-control studies. However, adjustment for potentially confounding measures such as smoking or season, and standardization of laboratory methods, are needed to confirm this association.
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