ArticleRNA (New York, N.Y.)2002
Cotranscriptional editing of Physarum mitochondrial RNA requires local features of the native template.
Article in RNA (New York, N.Y.), 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- A specific, promoter-independent activity of T7 RNA polymerase suggests a general model for DNA/RNA editing in single subunit RNA Polymerases.Scientific reports · 2018Article
- Translating the epitranscriptome.Wiley interdisciplinary reviews. RNA · 2017Review
- Article
- Parallel Evolution and Lineage-Specific Expansion of RNA Editing in Ctenophores.Integrative and comparative biology · 2015Review
- Comparison of insertional RNA editing in Myxomycetes.PLoS computational biology · 2012Article
- When you can't trust the DNA: RNA editing changes transcript sequences.Cellular and molecular life sciences : CMLS · 2011Review
- RNA editing in six mitochondrial ribosomal protein genes of Didymium iridis.Current genetics · 2010Article
- Distinct roles for sequences upstream of and downstream from Physarum editing sites.RNA (New York, N.Y.) · 2009Article
- Non-DNA-templated addition of nucleotides to the 3' end of RNAs by the mitochondrial RNA polymerase of Physarum polycephalum.Molecular and cellular biology · 2008Article
- Discovery of new genes and deletion editing in Physarum mitochondria enabled by a novel algorithm for finding edited mRNAs.Nucleic acids research · 2005Article
- Unexpectedly complex editing patterns at dinucleotide insertion sites in Physarum mitochondria.Molecular and cellular biology · 2004Article
- Editing site recognition and nucleotide insertion are separable processes in Physarum mitochondria.The EMBO journal · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
RNAs in the mitochondrion of Physarum polycephalum are edited by the precise cotranscriptional addition of non-encoded nucleotides. Here we describe experiments to address the basis of editing specificity using a series of chimeric templates generated by either rearranging the DNA present in editing-competent mitochondrial transcription elongation complexes (mtTECs) or linking it to exogenous DNA. Notably, run-on transcripts synthesized from rearranged mtTECs are edited at the natural sites, even when different genes are ligated together, yet exogenous, deproteinized DNA does not support editing. Furthermore, the accuracy of nucleotide insertion in chimeric RNAs argues that any cis-acting determinants of cytidine insertion are limited to small regions surrounding editing sites. Taken together, these observations strongly suggest that template-associated factors affect read-out of the mitochondrial genome.
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Registered trials
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