ArticleJournal of clinical laboratory analysis2002
Reference distributions for serum iron and transferrin saturation: a practical, simple, and clinically relevant approach in a large cohort.
Article in Journal of clinical laboratory analysis, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Reference distributions for complement proteins C3 and C4: a comparison of a large cohort to the world's literature.Journal of clinical laboratory analysis · 2004Pooled it
- Reference distributions for serum iron and transferrin saturation: a comparison of a large cohort to the world's literature.Journal of clinical laboratory analysis · 2002Pooled it
- Developmental Trends in Serum Iron, Transferrin, and Transferrin Saturation From Birth to 12 Months.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
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- Selected Trace Elements and Their Impact on Redox Homeostasis in Eye Health.Biomolecules · 2024Review
- Iron Metabolism and Inflammatory Mediators in Patients with Renal Dysfunction.International journal of molecular sciences · 2024Review
- Holo/apo conversion two-dimensional urea PAGE for speciation of FeAnalytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2024Article
- Evaluation of perturbed iron-homeostasis in a prospective cohort of patients with COVID-19.Wellcome open research · 2022Article
- Urea Gel Electrophoresis in Studies of Conformational Changes of Transferrin on Binding and Transport of Non-Ferric Metal Ions.Gels (Basel, Switzerland) · 2021Article
- Adaptive immunity and vaccination - iron in the spotlight.Immunotherapy advances · 2021Review
- A New Transferrin Receptor Aptamer Inhibits New World Hemorrhagic Fever Mammarenavirus Entry.Molecular therapy. Nucleic acids · 2016Article
- An RNA alternative to human transferrin: a new tool for targeting human cells.Molecular therapy. Nucleic acids · 2012Article
- The neglected significance of "antioxidative stress".Oxidative medicine and cellular longevity · 2012Review
- Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases.BMC medical genomics · 2009Article
- Sex- and age-dependent association of SLC11A1 polymorphisms with tuberculosis in Chinese: a case control study.BMC infectious diseases · 2007Article
- Reference distributions for apolipoproteins AI and B and the apolipoprotein B/AI ratios: a practical and clinically relevant approach in a large cohort.Journal of clinical laboratory analysis · 2006Article
- Reference distributions for alpha2-macroglobulin: a practical, simple and clinically relevant approach in a large cohort.Journal of clinical laboratory analysis · 2004Article
- Reference distributions for complement proteins C3 and C4: a practical, simple and clinically relevant approach in a large cohort.Journal of clinical laboratory analysis · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The principal considerations driving iron status evaluation are clinical concern for anemia and the possibility of iron-storage disease. Most often, the circulating levels of transferrin (or total iron binding capacity) and serum iron are measured and the percentage of transferrin saturation (TSAT) is then computed. Optimally, reference ranges for these analytes should exclude the effects of the acute phase response, nutritional status, estrogen effect, specific genetic disorders, liver disease, and blood transfusion. The current study reports reference ranges for serum iron and TSAT within a cohort of over 55,000 Caucasians from northern New England, tested in our laboratory between 1994 and 1999. Measurements were standardized against serum reference material (SRM) 937 (for iron) and certified reference material (CRM) 470 (also called reference preparation for proteins in human serum (RPPHS)) (for transferrin), and analyzed using a previously published approach. Individual cases with evidence of inflammation (C-reactive protein > or =10 mg/L), or iron overload (TSAT >80% for males and >70% for females) or serum iron values <5 micro mol/L, were removed. Among the referent individuals, iron and TSAT levels rose slightly until the teen years, at which time levels in males increased while those in females remained essentially constant. Between 20 and 70 years of age, males had 10-15% higher iron levels and 15-20% higher TSAT levels than females. When values were expressed as multiples of the age- and gender-specific median levels, the serum iron and TSAT observations fit log-Gaussian distributions reasonably well from the 20th to 99th centile, and the 10th to the 99th centile, respectively. After normalization, the Gaussian parameters can be used to assign a corresponding centile to an individual's measurement, simplifying interpretation. These data provide new and more detailed reference ranges for serum iron and TSAT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.