ReviewLeukemia2002
Variations on a theme: the alternate translocations in APL.
Review in Leukemia, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
51 citing papers in PubMed, 132 citations in OpenAlex.
- Targeting USP2 induces degradation of PML-RARα with or without drug-resistant mutations in acute promyelocytic leukemia.Acta biochimica et biophysica Sinica · 2025Article
- Detection of cytogenetically cryptic PML-RARA fusion in acute promyelocytic leukemia by rapid next generation sequencing.NPJ precision oncology · 2025Article
- Different Isoforms of PML-RARA Chimeric Protein in Patients with Acute Promyelocytic Leukemia: Survival Analysis per Demographic Characteristics, Clinicohematological Parameters, and Cytogenetic Findings.Iranian journal of pathology · 2023Article
- An Outcome Analysis of Childhood Acute Promyelocytic Leukemia Treated with Atra and Arsenic Trioxide, and Limited Dose Anthracycline.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2021Article
- Treatment Outcome and the Genetic Characteristics of Acute Promyelocytic Leukemia in Children in Poland From 2005 to 2018.Frontiers in pediatrics · 2020Article
- The genetics and clinical characteristics of children morphologically diagnosed as acute promyelocytic leukemia.Leukemia · 2019Article
- Secretome profiling of heterotypic spheroids suggests a role of fibroblasts in HIF-1 pathway modulation and colorectal cancer photodynamic resistance.Cellular oncology (Dordrecht, Netherlands) · 2019Article
- Structural Variants as a Basis for Targeted Therapies in Hematological Malignancies.Frontiers in oncology · 2019Review
- IRF2BP2-RARA t(1;17)(q42.3;q21.2) APL blasts differentiate in response to all-trans retinoic acid.Leukemia & lymphoma · 2018Article
- A case of acute myeloid leukemia with promyelocytic features characterized by expression of a novelBlood advances · 2018Article
- [Effects of NPM1 gene expression on acute myeloid leukemia cell lines and its mechanism].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2017Article
- The discussion of t(1;17)(p11;q21) translocation in acute promyelocytic leukemia patient on molecular remission.Clinical case reports · 2017Article
- Galectin-12 inhibits granulocytic differentiation of human NB4 promyelocytic leukemia cells while promoting lipogenesis.Journal of leukocyte biology · 2016Article
- Comprehensive mutational analysis of primary and relapse acute promyelocytic leukemia.Leukemia · 2016Article
- The leukemic oncoprotein NPM1-RARA inhibits TP53 activity.Leukemia & lymphoma · 2016Article
- Microgranular variant of acute promyelocytic leukemia with der(17) ins(17;15): A case report and review of the literature.Experimental and therapeutic medicine · 2015Article
- Global characteristics of childhood acute promyelocytic leukemia.Blood reviews · 2015Review
- Coexistence of t(15;17) and t(15;16;17) detected by fluorescenceOncology letters · 2014Article
- Extrinsic apoptosis is impeded by direct binding of the APL fusion protein NPM-RAR to TRADD.Molecular cancer research : MCR · 2014Article
- The PML domain of PML-RARα blocks senescence to promote leukemia.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The t(15;17)(q22;q21) translocation is tightly linked to the APL phenotype, and the resultant PML-RAR fusion can be demonstrated in 98% of APL cases. Rare variant translocations have been reported, the majority of which on detailed analysis represent cryptic PML-RAR fusions. However, a handful of APL cases have been described with different genotypes. These include the t(11;17)(q23;q21) that produces the PLZF-RAR fusion, t(5;17)(q35;q21) that forms NPM-RAR, t(11;17)(q13;q21) that generates NUMA-RAR, and der(17) that creates STAT5b-RAR. In this review we will discuss these variant translocations, and discuss the insights that we have gained from their study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.