ArticleThe Journal of physiology2002
Activation of store-operated channels by noradrenaline via protein kinase C in rabbit portal vein myocytes.
Article in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 96 citations in OpenAlex.
- Obligatory role for PKCδ in PIPThe Journal of physiology · 2020Article
- Insights into Activation Mechanisms of Store-Operated TRPC1 Channels in Vascular Smooth Muscle.Cells · 2020Review
- Store depletion induces Gαq-mediated PLCβ1 activity to stimulate TRPC1 channels in vascular smooth muscle cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- Transient Receptor Potential Channel 1 Deficiency Impairs Host Defense and Proinflammatory Responses to Bacterial Infection by Regulating Protein Kinase Cα Signaling.Molecular and cellular biology · 2015Article
- Activation of transient receptor potential canonical 3 (TRPC3)-mediated Ca2+ entry by A1 adenosine receptor in cardiomyocytes disturbs atrioventricular conduction.The Journal of biological chemistry · 2012Article
- Pharmacological profile of phosphatidylinositol 3-kinases and related phosphatidylinositols mediating endothelin(A) receptor-operated native TRPC channels in rabbit coronary artery myocytes.British journal of pharmacology · 2012Article
- Orai1 interacts with STIM1 and mediates capacitative Ca2+ entry in mouse pulmonary arterial smooth muscle cells.American journal of physiology. Cell physiology · 2010Article
- Altered protein kinase C regulation of pulmonary endothelial store- and receptor-operated Ca2+ entry after chronic hypoxia.The Journal of pharmacology and experimental therapeutics · 2010Article
- Ins(1,4,5)P3 interacts with PIP2 to regulate activation of TRPC6/C7 channels by diacylglycerol in native vascular myocytes.The Journal of physiology · 2010Article
- ROS-dependent signaling mechanisms for hypoxic Ca(2+) responses in pulmonary artery myocytes.Antioxidants & redox signaling · 2010Review
- FM dyes enter via a store-operated calcium channel and modify calcium signaling of cultured astrocytes.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Activation of native TRPC1/C5/C6 channels by endothelin-1 is mediated by both PIP3 and PIP2 in rabbit coronary artery myocytes.The Journal of physiology · 2009Article
- TRPC1 and STIM1 mediate capacitative Ca2+ entry in mouse pulmonary arterial smooth muscle cells.The Journal of physiology · 2009Article
- Obligatory role for phosphatidylinositol 4,5-bisphosphate in activation of native TRPC1 store-operated channels in vascular myocytes.The Journal of physiology · 2009Article
- Diverse properties of store-operated TRPC channels activated by protein kinase C in vascular myocytes.The Journal of physiology · 2008Article
- Multiple activation mechanisms of store-operated TRPC channels in smooth muscle cells.The Journal of physiology · 2007Review
- Angiotensin II activates two cation conductances with distinct TRPC1 and TRPC6 channel properties in rabbit mesenteric artery myocytes.The Journal of physiology · 2006Article
- On the activation mechanism of store-operated calcium channels.Pflugers Archiv : European journal of physiology · 2006Review
- Dual effect of calmodulin on store-operated Ca2+ -permeable cation channels in rabbit portal vein myocytes.British journal of pharmacology · 2006Article
- Signal transduction pathways and gating mechanisms of native TRP-like cation channels in vascular myocytes.The Journal of physiology · 2006Review
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2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present study we have investigated the role of diacylglycerol (DAG) and protein kinase C (PKC) in mediating activation of Ca(2+)-permeable store-operated channels (SOCs) by noradrenaline in rabbit portal vein smooth muscle cells. With cell-attached recording, bath application of noradrenaline, 1-oleoyl-acetyl-sn-glycerol (OAG) and phorbol 12,13-dibutyrate (PDBu) evoked single channel currents. The biophysical properties of these channel currents were similar to those of the channel currents activated by depletion of internal Ca(2+) stores with cyclopiazonic acid (CPA). The activation of SOCs in cell-attached recording by noradrenaline, OAG, PDBu, CPA and the acetoxymethyl ester form of BAPTA (BAPTA-AM) was markedly inhibited by the PKC inhibitors chelerythrine and RO-31-8220. In isolated outside-out patches CPA did not evoke SOCs but noradrenaline stimulated SOC activity, which was reduced by about 90 % by PKC inhibitors. The addition of the serine/threonine phosphatase inhibitors calyculin A and microcystin also stimulated SOCs in isolated outside-out patches. It is concluded that in rabbit portal vein myocytes, noradrenaline activates SOCs via DAG and PKC, possibly by a store-independent mechanism. In addition in this cell type it appears that PKC and phosphorylation may play an important role in stimulating SOC activity in response to depletion of internal Ca(2+) stores by CPA and BAPTA-AM.
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