ArticleThe Journal of physiology2002
Nicotinic acid adenine dinucleotide phosphate (NAADP) is present at micromolar concentrations in sea urchin spermatozoa.
Article in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 54 citations in OpenAlex.
- Chemo-enzymatic synthesis of adenine substituted nicotinic acid adenine dinucleotide phosphate (NAADP) analogs.Bioorganic & medicinal chemistry · 2021Article
- Regulation and roles of Ca2+ stores in human sperm.Reproduction (Cambridge, England) · 2015Review
- Two-Pore Channels: Lessons from Mutant Mouse Models.Messenger (Los Angeles, Calif. : Print) · 2015Article
- Autocrine/paracrine function of nicotinic acid adenine dinucleotide phosphate (NAADP) for glucose homeostasis in pancreatic β-cells and adipocytes.The Journal of biological chemistry · 2013Article
- Calcium pathway machinery at fertilization in echinoderms.Cell calcium · 2013Review
- Cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate (NAADP) as messengers for calcium mobilization.The Journal of biological chemistry · 2012Review
- The calcium-mobilizing messenger nicotinic acid adenine dinucleotide phosphate participates in sperm activation by mediating the acrosome reaction.The Journal of biological chemistry · 2010Article
- Molecular characterization of a novel cell surface ADP-ribosyl cyclase from the sea urchin.Cellular signalling · 2008Article
- Calcium signalling in early embryos.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2008Review
- Refinement of a radioreceptor binding assay for nicotinic acid adenine dinucleotide phosphate.Analytical biochemistry · 2007Article
- Article
- Calcium at fertilization and in early development.Physiological reviews · 2006Review
- NAADP binding to its target protein in sea urchin eggs requires phospholipids.The Biochemical journal · 2005Article
- Triazine dyes are agonists of the NAADP receptor.British journal of pharmacology · 2004Article
- Determination of cellular nicotinic acid-adenine dinucleotide phosphate (NAADP) levels.The Biochemical journal · 2004Article
- Production and characterization of reduced NAADP (nicotinic acid-adenine dinucleotide phosphate).The Biochemical journal · 2004Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nicotinic acid adenine dinucleotide phosphate (NAADP) has been shown to induce Ca(2+) release in numerous cellular models, ranging from marine invertebrates to mammals. However, endogenous levels of this pyridine dinucleotide have yet to be demonstrated. In the sea urchin egg, NAADP receptors are abundant but have the peculiarity of being inactivated at low concentrations (picomolar) and activated at higher concentrations (nanomolar) which apparently rules out any possibility of the receptor being activated by concentration rises induced by a slow enzymatic formation in the cytosol. One of the most important events of fertilization is a Ca(2+) transient in the egg, which leads to egg activation. The mechanisms which underlie the transient are still unclear and several theories persist including the existence of a sperm receptor and that soluble factors may pass from the sperm to the egg cytosol. We have investigated the possibility that NAADP might be present in sperm. Indeed, we found that sea water-activated spermatozoa are able to synthesize NAADP and that sperm extracts contain micromolar concentrations of the messenger. Although it is unlikely that NAADP alone mediates the fertilization wave, our data suggest that transfer of NAADP from spermatozoa to egg may play a role in this phenomenon.
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