ArticleThe Journal of physiology2002
Sarcoplasmic reticulum calcium load regulates rat arterial smooth muscle calcium sparks and transient K(Ca) currents.
Article in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Ryanodine receptor cluster remodeling linksbioRxiv : the preprint server for biology · 2026Article
- Potassium channels in vascular smooth muscle cells.Physiological reviews · 2026Review
- Aldosterone increases the expression and subcellular localization of SERCA2a and SERCA2b in the rat mesenteric artery.Frontiers in physiology · 2026Article
- Insulin resistance, CaFrontiers in physiology · 2025Review
- PKC Inhibits Sec61 Translocon-Mediated Sarcoplasmic Reticulum CaFrontiers in physiology · 2022Article
- Aldosterone-Induced Sarco/Endoplasmic Reticulum CaFrontiers in physiology · 2022Article
- Aging alters spontaneous and neurotransmitter-mediated CaMicrocirculation (New York, N.Y. : 1994) · 2020Article
- Reduced CaAging · 2020Article
- Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles.Comprehensive Physiology · 2017Review
- Interplay among distinct CaThe Journal of physiology · 2017Article
- Hypoxia-dependent reactive oxygen species signaling in the pulmonary circulation: focus on ion channels.Antioxidants & redox signaling · 2015Review
- Constitutive PKA activity is essential for maintaining the excitability and contractility in guinea pig urinary bladder smooth muscle: role of the BK channel.American journal of physiology. Cell physiology · 2014Article
- Type 2 ryanodine receptors are highly sensitive to alcohol.FEBS letters · 2014Article
- Article
- Antenatal hypoxia and pulmonary vascular function and remodeling.Current vascular pharmacology · 2013Review
- Calcium dynamics in vascular smooth muscle.Microcirculation (New York, N.Y. : 1994) · 2013Review
- Ion channel remodeling in vascular smooth muscle during hypertension: Implications for novel therapeutic approaches.Pharmacological research · 2013Review
- Abnormal Ca2+ spark/STOC coupling in cerebral artery smooth muscle cells of obese type 2 diabetic mice.PloS one · 2013Article
- Hydrogen sulfide activates Ca²⁺ sparks to induce cerebral arteriole dilatation.The Journal of physiology · 2012Article
- Relationship between Ca2+ sparklets and sarcoplasmic reticulum Ca2+ load and release in rat cerebral arterial smooth muscle.American journal of physiology. Heart and circulatory physiology · 2011Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The regulation of calcium (Ca(2+)) sparks and transient calcium-sensitive K(+) (K(Ca)) currents by acute changes in sarcoplasmic reticulum (SR) Ca(2+) load ([Ca(2+)](SR)) was investigated in rat cerebral artery smooth muscle cells using laser-scanning confocal microscopy in combination with patch clamp electrophysiology. [Ca(2+)](SR) was elevated by: (i) increasing the activity of the SR Ca(2+)-ATPase with an anti-phospholamban monoclonal antibody, or (ii) blocking Ca(2+) release from the SR with tetracaine, a membrane-permeant, reversible ryanodine-sensitive Ca(2+) release (RyR) channel blocker. Alternatively, [Ca(2+)](SR) was progressively decreased over time with a low concentration of thapsigargin (20 nM), a SR Ca(2+)-ATPase blocker. An elevation in [Ca(2+)](SR) increased Ca(2+) spark and transient K(Ca) current frequency, but did not alter the amplitude, decay or spatial spread of Ca(2+) sparks or the coupling ratio or amplitude correlation between Ca(2+) sparks and evoked transient K(Ca) currents. Decreasing [Ca(2+)](SR) reduced Ca(2+) spark frequency, amplitude and spatial spread and this reduced transient K(Ca) current frequency and amplitude. However, even when mean Ca(2+) spark amplitude and spread decreased by up to 47 and 56 % of control, respectively, the coupling ratio or amplitude correlation between Ca(2+) sparks and transient K(Ca) currents was not affected. These data demonstrate that acute changes in [Ca(2+)](SR) regulate Ca(2+) sparks and transient K(Ca) currents in arterial smooth muscle cells.
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