ArticleThe Journal of cell biology2002
Functional role of epsilon-tubulin in the assembly of the centriolar microtubule scaffold.
Article in The Journal of cell biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- The γ-TuRC: mastermind of multipurpose actions at the centrosome.Cellular and molecular life sciences : CMLS · 2026Review
- A basal body microtubule singlet-to-doublet transition in Plasmodium male gametogenesis.Nature communications · 2025Article
- A delta-tubulin/epsilon-tubulin/Ted protein complex is required for centriole architecture.eLife · 2025Article
- Epsilon tubulin is an essential determinant of microtubule-based structures in male germ cells.EMBO reports · 2024Article
- The evolutionary conserved proteins CEP90, FOPNL, and OFD1 recruit centriolar distal appendage proteins to initiate their assembly.PLoS biology · 2022Article
- Review
- The Cilioprotist Cytoskeleton , a Model for Understanding How Cell Architecture and Pattern Are Specified: Recent Discoveries from Ciliates and Comparable Model Systems.Methods in molecular biology (Clifton, N.J.) · 2022Review
- Phylogenomics of a new fungal phylum reveals multiple waves of reductive evolution across Holomycota.Nature communications · 2021Article
- CEP44 ensures the formation of bona fide centriole wall, a requirement for the centriole-to-centrosome conversion.Nature communications · 2020Article
- The Structural and Molecular Underpinnings of Gametogenesis inFrontiers in cellular and infection microbiology · 2020Review
- Polarity in Ciliate Models: From Cilia to Cell Architecture.Frontiers in cell and developmental biology · 2019Review
- Motile Cilia: Innovation and Insight From Ciliate Model Organisms.Frontiers in cell and developmental biology · 2019Review
- Review
- Cell polarity: having and making sense of direction-on the evolutionary significance of the primary cilium/centrosome organ in Metazoa.Open biology · 2018Review
- A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.Nature genetics · 2018Article
- Katanin-like 2 (KATNAL2) functions in multiple aspects of haploid male germ cell development in the mouse.PLoS genetics · 2017Article
- Centriole triplet microtubules are required for stable centriole formation and inheritance in human cells.eLife · 2017Article
- The ABCs of Centriole Architecture: The Form and Function of Triplet Microtubules.Cold Spring Harbor symposia on quantitative biology · 2017Article
- Paramecium tetraurelia basal body structure.Cilia · 2015Review
- Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Centrioles and basal bodies fascinate by their spectacular architecture, featuring an arrangement of nine microtubule triplets into an axial symmetry, whose biogenesis relies on yet elusive mechanisms. However, the recent discovery of new tubulins, such as delta-, epsilon-, or eta-tubulin, could constitute a breakthrough for deciphering the assembly steps of this unconventional microtubule scaffold. Here, we report the functional analysis in vivo of epsilon-tubulin, based on gene silencing in Paramecium, which demonstrates that this protein, which localizes at the basal bodies, is essential for the assembly and anchorage of the centriolar microtubules.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.