ArticleThe Journal of cell biology2002
Phosphorylation and an ATP-dependent process increase the dynamic exchange of H1 in chromatin.
Article in The Journal of cell biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 87 citations in OpenAlex.
- Chromatin accessibility: biological functions, molecular mechanisms and therapeutic application.Signal transduction and targeted therapy · 2024Review
- Chromatin transitions triggered by LH density as epigenetic regulators of the genome.Nucleic acids research · 2022Article
- Article
- H1 histones: current perspectives and challenges.Nucleic acids research · 2013Review
- Pin1 promotes histone H1 dephosphorylation and stabilizes its binding to chromatin.The Journal of cell biology · 2013Article
- Crucial role of dynamic linker histone binding and divalent ions for DNA accessibility and gene regulation revealed by mesoscale modeling of oligonucleosomes.Nucleic acids research · 2012Article
- Base excision repair of 8-oxoG in dinucleosomes.Nucleic acids research · 2012Article
- Histone h1 depletion impairs embryonic stem cell differentiation.PLoS genetics · 2012Article
- The effect of linker histone's nucleosome binding affinity on chromatin unfolding mechanisms.Biophysical journal · 2011Article
- Nucleosomes in the neighborhood: new roles for chromatin modifications in replication origin control.Epigenetics · 2011Review
- Histone H2A C-terminus regulates chromatin dynamics, remodeling, and histone H1 binding.PLoS genetics · 2010Article
- Article
- Modules for C-terminal epitope tagging of Tetrahymena genes.Journal of microbiological methods · 2010Article
- Drosophila ISWI regulates the association of histone H1 with interphase chromosomes in vivo.Genetics · 2009Article
- Functional evolution of cyclin-dependent kinases.Molecular biotechnology · 2009Review
- Visualizing chromatin dynamics in intact cells.Biochimica et biophysica acta · 2008Review
- Global changes in and characterization of specific sites of phosphorylation in mouse and human histone H1 Isoforms upon CDK inhibitor treatment using mass spectrometry.Journal of proteome research · 2008Article
- Histone H1 of Trypanosoma cruzi is concentrated in the nucleolus region and disperses upon phosphorylation during progression to mitosis.Eukaryotic cell · 2008Article
- Class I histone deacetylase Thd1p promotes global chromatin condensation in Tetrahymena thermophila.Eukaryotic cell · 2007Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In Tetrahymena cells, phosphorylation of linker histone H1 regulates transcription of specific genes. Phosphorylation acts by creating a localized negative charge patch and phenocopies the loss of H1 from chromatin, suggesting that it affects transcription by regulating the dissociation of H1 from chromatin. To test this hypothesis, we used FRAP of GFP-tagged H1 to analyze the effects of mutations that either eliminate or mimic phosphorylation on the binding of H1 to chromatin both in vivo and in vitro. We demonstrate that phosphorylation can increase the rate of dissociation of H1 from chromatin, providing a mechanism by which it can affect H1 function in vivo. We also demonstrate a previously undescribed ATP-dependent process that has a global effect on the dynamic binding of linker histone to chromatin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.