ArticleThe EMBO journal2002
Differential accessibility at the kappa chain locus plays a role in allelic exclusion.
Article in The EMBO journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Clinical immunology in chromatinopathies: a scoping review.Frontiers in immunology · 2026Article
- Asynchronous Replication Timing: A Mechanism for Monoallelic Choice During Development.Frontiers in cell and developmental biology · 2021Review
- Clonally stable Vκ allelic choice instructs Igκ repertoire.Nature communications · 2017Article
- A novel pax5-binding regulatory element in the igκ locus.Frontiers in immunology · 2014Article
- Epigenetic regulation of monoallelic rearrangement (allelic exclusion) of antigen receptor genes.Frontiers in immunology · 2014Review
- Epigenetics of haematopoietic cell development.Nature reviews. Immunology · 2011Review
- Epigenetic control of recombination in the immune system.Seminars in immunology · 2010Review
- Allelic exclusion of immunoglobulin genes: models and mechanisms.Immunological reviews · 2010Review
- Biallelic, ubiquitous transcription from the distal germline Ig{kappa} locus promoter during B cell development.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Immunoglobulin kappa enhancers are differentially regulated at the level of chromatin structure.Molecular immunology · 2007Article
- Germline transcription from T-cell receptor Vbeta gene is uncoupled from allelic exclusion.The EMBO journal · 2007Article
- Critical roles of the immunoglobulin intronic enhancers in maintaining the sequential rearrangement of IgH and Igk loci.The Journal of experimental medicine · 2006Article
- Light chain inclusion permits terminal B cell differentiation and does not necessarily result in autoreactivity.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene rearrangement in the immune system is always preceded by DNA demethylation and increased chromatin accessibility. Using a model system in which rearrangement of the endogenous immunoglobulin kappa locus is prevented, we demonstrate that these epigenetic and chromatin changes actually occur on one allele with a higher probability than the other. It may be this process that, together with feedback inhibition, serves as the basis for allelic exclusion.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.