ArticleThe EMBO journal2002
Baculovirus apoptotic suppressor P49 is a substrate inhibitor of initiator caspases resistant to P35 in vivo.
Article in The EMBO journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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Who cites it
42 citing papers in PubMed, 89 citations in OpenAlex.
- Apoptosis or Antiapoptosis? Interrupted Regulated Cell Death of Host Cells by Ascovirus InfectionmBio · 2023Article
- A long way to go: caspase inhibitors in clinical use.Cell death & disease · 2021Review
- Identification and Functional Analysis of Apoptotic Protease Activating Factor-1 (Apaf-1) fromInsects · 2021Article
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- Vaccinia Virus Encodes a Novel Inhibitor of Apoptosis That Associates with the Apoptosome.Journal of virology · 2017Article
- SfDredd, a Novel Initiator Caspase Possessing Activity on Effector Caspase Substrates in Spodoptera frugiperda.PloS one · 2016Article
- Baculovirus Inhibitor-of-Apoptosis Op-IAP3 Blocks Apoptosis by Interaction with and Stabilization of a Host Insect Cellular IAP.Journal of virology · 2016Article
- Reaching the melting point: Degradative enzymes and protease inhibitors involved in baculovirus infection and dissemination.Virology · 2015Review
- Novel apoptosis suppressor Apsup from the baculovirus Lymantria dispar multiple nucleopolyhedrovirus precludes apoptosis by preventing proteolytic processing of initiator caspase Dronc.Journal of virology · 2013Article
- Phosphorylation drives an apoptotic protein to activate antiapoptotic genes: paradigm of influenza A matrix 1 protein function.The Journal of biological chemistry · 2013Article
- SfDronc, an initiator caspase involved in apoptosis in the fall armyworm Spodoptera frugiperda.Insect biochemistry and molecular biology · 2013Article
- Baculoviruses modulate a proapoptotic DNA damage response to promote virus multiplication.Journal of virology · 2012Article
- Enhanced recombinant protein production and differential expression of molecular chaperones in sf-caspase-1-repressed stable cells after baculovirus infection.BMC biotechnology · 2012Article
- Caspase cleavage of viral proteins, another way for viruses to make the best of apoptosis.Cell death & disease · 2012Review
- Toward system-level understanding of baculovirus-host cell interactions: from molecular fundamental studies to large-scale proteomics approaches.Frontiers in microbiology · 2012Article
- Caspase inhibitors of the P35 family are more active when purified from yeast than bacteria.PloS one · 2012Article
- Functional and biochemical characterization of the baculovirus caspase inhibitor MaviP35.Cell death & disease · 2011Article
- Active depletion of host cell inhibitor-of-apoptosis proteins triggers apoptosis upon baculovirus DNA replication.Journal of virology · 2011Article
- Induction of reaper ortholog mx in mosquito midgut cells following baculovirus infection.Cell death and differentiation · 2011Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
Caspases play a critical role in the execution of metazoan apoptosis and are thus attractive therapeutic targets for apoptosis-associated diseases. Here we report that baculovirus P49, a homolog of pancaspase inhibitor P35, prevents apoptosis in invertebrates by inhibiting an initiator caspase that is P35 insensitive. Consequently P49 blocked proteolytic activation of effector caspases at a unique step upstream from that affected by P35 but downstream from inhibitor of apoptosis Op-IAP. Like P35, P49 was cleaved by and stably associated with its caspase target. Ectopically expressed P49 blocked apoptosis in cultured cells from a phylogenetically distinct organism, Drosophila melanogaster. Furthermore, P49 inhibited human caspase-9, demonstrating its capacity to affect a vertebrate initiator caspase. Thus, P49 is a substrate inhibitor with a novel in vivo specificity for a P35-insensitive initiator caspase that functions at an evolutionarily conserved step in the caspase cascade. These data indicate that activated initiator caspases provide another effective target for apoptotic intervention by substrate inhibitors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.