ArticleThe EMBO journal2002
A novel vasopressin-induced transcript promotes MAP kinase activation and ENaC downregulation.
Article in The EMBO journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 45 citations in OpenAlex.
- Predicting patient outcomes with gene-expression biomarkers from colorectal cancer organoids and cell lines.Frontiers in molecular biosciences · 2025Article
- Microarray evidence that 8-cell human embryos express some hormone family members including oxytocin.Journal of assisted reproduction and genetics · 2024Article
- Autophagy-prominent cell clusters among human lens epithelial cells: integrated single-cell RNA-sequencing analysis.BMC ophthalmology · 2023Article
- Review
- Nuclear transcriptional changes in hypothalamus of Pomc enhancer knockout mice after excessive alcohol drinking.Genes, brain, and behavior · 2019Article
- An LHX1-Regulated Transcriptional Network Controls Sleep/Wake Coupling and Thermal Resistance of the Central Circadian Clockworks.Current biology : CB · 2017Article
- Sodium channel γENaC mediates IL-17 synergized high salt induced inflammatory stress in breast cancer cells.Cellular immunology · 2016Article
- Human Thyroid Cancer-1 (TC-1) is a vertebrate specific oncogenic protein that protects against copper and pro-apoptotic genes in yeast.Microbial cell (Graz, Austria) · 2015Article
- H-Ras mediates the inhibitory effect of epidermal growth factor on the epithelial Na+ channel.PloS one · 2015Article
- Role of epithelial sodium channels and their regulators in hypertension.The Journal of biological chemistry · 2010Review
- Lipopolysaccharide modifies amiloride-sensitive Na+ transport processes across human airway cells: role of mitogen-activated protein kinases ERK 1/2 and 5.Pflugers Archiv : European journal of physiology · 2010Article
- Epithelial sodium channel regulated by differential composition of a signaling complex.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Regulated sodium transport in the renal connecting tubule (CNT) via the epithelial sodium channel (ENaC).Pflugers Archiv : European journal of physiology · 2009Review
- Acute downregulation of ENaC by EGF involves the PY motif and putative ERK phosphorylation site.The Journal of general physiology · 2007Article
- Negative regulators of sodium transport in the kidney: key factors in understanding salt-sensitive hypertension?The Journal of clinical investigation · 2003Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the principal cell of the renal collecting duct, vasopressin regulates the expression of a gene network responsible for sodium and water reabsorption through the regulation of the water channel and the epithelial sodium channel (ENaC). We have recently identified a novel vasopressin-induced transcript (VIT32) that encodes for a 142 amino acid vasopressin-induced protein (VIP32), which has no homology with any protein of known function. The Xenopus oocyte expression system revealed two functions: (i) when injected alone, VIT32 cRNA rapidly induces oocyte meiotic maturation through the activation of the maturation promoting factor, the amphibian homolog of the universal M phase trigger Cdc2/cyclin; and (ii) when co-injected with the ENaC, VIT32 cRNA selectively downregulates channel activity, but not channel cell surface expression. In the kidney principal cell, VIP32 may be involved in the downregulation of transepithelial sodium transport observed within a few hours after vasopressin treatment. VIP32 belongs to a novel gene family ubiquitously expressed in oocyte and somatic cells that may be involved in G to M transition and cell cycling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.