ArticleThe EMBO journal2002
Quantitative proteomic analysis of Myc oncoprotein function.
Article in The EMBO journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it, 182 citations in OpenAlex.
- Using proteomics to advance the search for potential biomarkers for preeclampsia: A systematic review and meta-analysis.PloS one · 2019Pooled it
- To Erase or Not to Erase: Non-Canonical Catalytic Functions and Non-Catalytic Functions of Members of Histone Lysine Demethylase Families.International journal of molecular sciences · 2024Review
- Isoform-Directed Control of c-Myc Functions: Understanding the Balance from Proliferation to Growth Arrest.International journal of molecular sciences · 2023Review
- KITENIN promotes aerobic glycolysis through PKM2 induction by upregulating the c-Myc/hnRNPs axis in colorectal cancer.Cell & bioscience · 2023Article
- High ARHGEF2 (GEF-H1) Expression is Associated with Poor Prognosis Via Cell Cycle Regulation in Patients with Pancreatic Cancer.Annals of surgical oncology · 2021Article
- An "-omycs" Toolbox to Work with MYC.Methods in molecular biology (Clifton, N.J.) · 2021Article
- TGF-β1 Induces Polypyrimidine Tract-Binding Protein to Alter Fibroblasts Proliferation and Fibronectin Deposition in Keloid.Scientific reports · 2016Article
- Functional proteomics identifies miRNAs to target a p27/Myc/phospho-Rb signature in breast and ovarian cancer.Oncogene · 2016Article
- Article
- Complexity in cancer biology: is systems biology the answer?Cancer medicine · 2013Review
- Molecular Characteristics in MRI-Classified Group 1 Glioblastoma Multiforme.Frontiers in oncology · 2013Article
- Wnt antagonist SFRP1 functions as a secreted mediator of senescence.Molecular and cellular biology · 2012Article
- Plasminogen activator inhibitor 1--insulin-like growth factor binding protein 3 cascade regulates stress-induced senescence.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- The interaction of the von Hippel-Lindau tumor suppressor and heterochromatin protein 1.Archives of biochemistry and biophysics · 2012Article
- MicroRNA-34a suppresses malignant transformation by targeting c-Myc transcriptional complexes in human renal cell carcinoma.Carcinogenesis · 2012Article
- Drosophila poly suggests a novel role for the Elongator complex in insulin receptor-target of rapamycin signalling.Open biology · 2012Article
- Comparative proteomic analysis of a cytosolic fraction from β3 integrin-deficient cells.Cancer genomics & proteomics · 2012Article
- Finding cancer's weakest link.Oncotarget · 2011Review
- Proteomic dissection of the von Hippel-Lindau (VHL) interactome.Journal of proteome research · 2011Article
- Quantitative proteomic identification of the BRCA1 ubiquitination substrates.Journal of proteome research · 2011Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study applies a new quantitative proteomics technology to the analysis of the function of the Myc oncoprotein in mammalian cells. Employing isotope-coded affinity tag (ICAT) reagent labeling and tandem mass spectrometry, the global pattern of protein expression in rat myc-null cells was compared with that of myc-plus cells (myc-null cells in which myc has been introduced) to generate a differential protein expression catalog. Expression differences among many functionally related proteins were identified, including reduction of proteases, induction of protein synthesis pathways and upregulation of anabolic enzymes in myc-plus cells, which are predicted to lead to increased cell mass (cell growth). In addition, reduction in the levels of adhesion molecules, actin network proteins and Rho pathway proteins were observed in myc-plus cells, leading to reduced focal adhesions and actin stress fibers as well as altered morphology. These effects are dependent on the highly conserved Myc Box II region. Our results reveal a novel cytoskeletal function for Myc and indicate the feasibility of quantitative whole-proteome analysis in mammalian cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.