ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
The switch of subthalamic neurons from an irregular to a bursting pattern does not solely depend on their GABAergic inputs in the anesthetic-free rat.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 60 citations in OpenAlex.
- Adaptive Stimulations in a Biophysical Network Model of Parkinson's Disease.International journal of molecular sciences · 2023Article
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- Anatomy and Connectivity of the Subthalamic Nucleus in Humans and Non-human Primates.Frontiers in neuroanatomy · 2020Review
- meaRtools: An R package for the analysis of neuronal networks recorded on microelectrode arrays.PLoS computational biology · 2018Article
- Deep Brain Stimulation for Movement Disorders of Basal Ganglia Origin: Restoring Function or Functionality?Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2016Review
- Anabolic steroids alter the physiological activity of aggression circuits in the lateral anterior hypothalamus.Neuroscience · 2016Article
- Sensitization of neurons in the central nucleus of the amygdala via the decreased GABAergic inhibition contributes to the development of neuropathic pain-related anxiety-like behaviors in rats.Molecular brain · 2014Article
- Short-term depression of external globus pallidus-subthalamic nucleus synaptic transmission and implications for patterning subthalamic activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Lessons learned from the transgenic Huntington's disease rats.Neural plasticity · 2012Review
- Modulation of subthalamic T-type Ca(2+) channels remedies locomotor deficits in a rat model of Parkinson disease.The Journal of clinical investigation · 2011Article
- Dendritic sodium channels promote active decorrelation and reduce phase locking to parkinsonian input oscillations in model globus pallidus neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Conditioned lick behavior and evoked responses using whisker twitches in head restrained rats.Behavioural brain research · 2009Article
- The treatment of movement disorders by deep brain stimulation.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2008Review
- Behavioral and in vitro correlates of compulsive-like food seeking induced by operant conditioning in Aplysia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Glutamate and GABA receptors and transporters in the basal ganglia: what does their subsynaptic localization reveal about their function?Neuroscience · 2006Review
- Distinct patterns of striatal medium spiny neuron activity during the natural sleep-wake cycle.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Electrophysiological diversity of the dorsal raphe cells across the sleep-wake cycle of the rat.The Journal of physiology · 2006Article
- Enhancement of excitatory synaptic integration by GABAergic inhibition in the subthalamic nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Globus pallidus neurons dynamically regulate the activity pattern of subthalamic nucleus neurons through the frequency-dependent activation of postsynaptic GABAA and GABAB receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Transient receptor potential-like channels mediate metabotropic glutamate receptor EPSCs in rat dopamine neurones.The Journal of physiology · 2004Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The subthalamic nucleus (STN) powerfully controls basal ganglia outputs and has been implicated in movement disorders observed in Parkinson's disease because of its pathological mixed burst firing mode and hyperactivity. A recent study suggested that reciprocally connected glutamatergic STN and GABAergic globus pallidus (GP) neurons act in vitro as a generator of bursting activity in basal ganglia. In vivo, we reported that GP neurons increased their firing rate in wakefulness (W) compared with slow-wave sleep (SWS) without any change in their random pattern. In contrast, STN neurons exhibited similar firing rates in W and SWS, with an irregular pattern in W and a bursty one in SWS. Thus, the pallidal GABAergic tone might control the STN pattern. This hypothesis was tested by mimicking such variations with microiontophoresis of GABA receptor ligands. GABA agonists specifically decreased the STN firing rate but did not affect its firing pattern. GABA(A) (but not GABA(B)) antagonists strongly enhanced the STN mean discharge rate during all vigilance states up to three to five times its basal activity. However, such applications did not change the typical W random pattern. When applied during SWS, GABA(A) antagonists strongly reinforced the spontaneous bursty pattern into a particularly marked one with instantaneous frequencies reaching 500-600 Hz. SWS-W transitions occurring during ongoing antagonist iontophoresis invariably disrupted the bursty pattern into a random one. Thus GABA(A) receptors play a critical, but not exclusive, role in regulating the excitatory STN influence on basal ganglia outputs.
Indexed as
Identifiers
12351741PMC6757798W2164850695What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.