ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Unilateral sensorimotor cortex lesions in adult rats facilitate motor skill learning with the "unaffected" forelimb and training-induced dendritic structural plasticity in the motor cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed.
- Corticomotor reorganization during short-term visuomotor training in the lower back: A randomized controlled study.Brain and behavior · 2020Trial
- Hemispheric specialization for movement control produces dissociable differences in online corrections after stroke.Cerebral cortex (New York, N.Y. : 1991) · 2012Trial
- Experience-driven competition in neural reorganization after stroke.The Journal of physiology · 2025Review
- Article
- Functional anomaly mapping reveals local and distant dysfunction caused by brain lesions.NeuroImage · 2020Article
- Changes in ipsilesional hand motor function differ after unilateral injury to frontal versus frontoparietal cortices in Macaca mulatta.Experimental brain research · 2020Article
- Brain Activation During Passive and Volitional Pedaling After Stroke.Motor control · 2019Article
- Training of the impaired forelimb after traumatic brain injury enhances hippocampal neurogenesis in the Emx1 null mice lacking a corpus callosum.Behavioural brain research · 2018Article
- Motor compensation and its effects on neural reorganization after stroke.Nature reviews. Neuroscience · 2017Review
- Proteome dynamics during postnatal mouse corpus callosum development.Scientific reports · 2017Article
- Vagus Nerve Stimulation During Rehabilitative Training Improves Forelimb Recovery After Chronic Ischemic Stroke in Rats.Neurorehabilitation and neural repair · 2016Article
- The Effect of Lesion Size on the Organization of the Ipsilesional and Contralesional Motor Cortex.Neurorehabilitation and neural repair · 2016Article
- Enduring Poststroke Motor Functional Improvements by a Well-Timed Combination of Motor Rehabilitative Training and Cortical Stimulation in Rats.Neurorehabilitation and neural repair · 2016Article
- Motor System Reorganization After Stroke: Stimulating and Training Toward Perfection.Physiology (Bethesda, Md.) · 2015Review
- Training Intensity Affects Motor Rehabilitation Efficacy Following Unilateral Ischemic Insult of the Sensorimotor Cortex in C57BL/6 Mice.Neurorehabilitation and neural repair · 2015Article
- Experience with the "good" limb induces aberrant synaptic plasticity in the perilesion cortex after stroke.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Attention-network specific alterations of structural connectivity in the undamaged white matter in acute neglect.Human brain mapping · 2014Article
- Sprouting of brainstem-spinal tracts in response to unilateral motor cortex stroke in mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Priming the brain to capitalize on metaplasticity in stroke rehabilitation.Physical therapy · 2014Review
- Motor cortex excitability in acute cerebellar infarct.Cerebellum (London, England) · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
In humans and other animals, sufficient unilateral damage to the sensorimotor cortex can cause impairments in the opposite forelimb and the development of a hyper-reliance on the nonimpaired limb. This hyper-reliance is adaptive to the extent that it contributes to functional compensation for lesion-induced impairments. We have found that unilateral lesions of the forelimb region of the sensorimotor cortex (FLsmc) in rats, or callosal transections, cause neurons of the opposite motor cortex to become exceptionally responsive to changes in forelimb behavior. This enhanced responsiveness might facilitate learning of compensatory strategies with the nonimpaired forelimb after unilateral FLsmc lesions. The possibility that these lesions facilitate learning with the nonimpaired forelimb was addressed in this study. Rats were required to learn a skilled forelimb reaching task after either unilateral FLsmc lesions or sham operations. The trained limb in animals with lesions was the nonimpaired limb. Compared with shams, rats with unilateral lesions had a greater rate of acquisition and asymptotic performance level on the task, which was especially evident on more difficult trials. Quantitative measures of microtubule associated protein-2 (MAP2) immunostained dendrites indicated an enhancement of training-induced dendritic cytoskeletal changes in the motor cortex opposite lesions. Thus, unilateral FLsmc lesions facilitate learning of at least some types of motor skills using the nonimpaired forelimb as well as some of the neuronal changes associated with this learning. This facilitation could be a substrate underlying behavioral compensation for unilateral FLsmc damage and may contribute to the phenomenon of learned nonuse of the impaired limb.
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12351733PMC6757779What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.