ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Disruption of early events in thalamocortical tract formation in mice lacking the transcription factors Pax6 or Foxg1.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 44 citations in OpenAlex.
- Analysis of downstream targets of PAX6 and LHX2, fundamental regulators of the developing mammalian neocortex.Journal of biosciences · 2025Article
- Foxg1 deletion impairs the development of the epithalamus.Molecular brain · 2018Article
- Imbalance of excitatory/inhibitory synaptic protein expression in iPSC-derived neurons from FOXG1(+/-) patients and in foxg1(+/-) mice.European journal of human genetics : EJHG · 2016Article
- Pax6 is required intrinsically by thalamic progenitors for the normal molecular patterning of thalamic neurons but not the growth and guidance of their axons.Neural development · 2015Article
- Horizontal Basal Cell-Specific Deletion of Pax6 Impedes Recovery of the Olfactory Neuroepithelium Following Severe Injury.Stem cells and development · 2015Article
- Cell-autonomous repression of Shh by transcription factor Pax6 regulates diencephalic patterning by controlling the central diencephalic organizer.Cell reports · 2014Article
- MiR-135b is a direct PAX6 target and specifies human neuroectoderm by inhibiting TGF-β/BMP signaling.The EMBO journal · 2014Article
- Identification of transcription factors for lineage-specific ESC differentiation.Stem cell reports · 2013Article
- Mechanisms controlling the guidance of thalamocortical axons through the embryonic forebrain.The European journal of neuroscience · 2012Review
- The lhx2 transcription factor controls thalamocortical axonal guidance by specific regulation of robo1 and robo2 receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- The importance of combinatorial gene expression in early Mammalian thalamic patterning and thalamocortical axonal guidance.Frontiers in neuroscience · 2012Article
- Normal ventral telencephalic expression of Pax6 is required for normal development of thalamocortical axons in embryonic mice.Neural development · 2009Article
- The role of Sonic hedgehog of neural origin in thalamic differentiation in the mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Pax6 controls cerebral cortical cell number by regulating exit from the cell cycle and specifies cortical cell identity by a cell autonomous mechanism.Developmental biology · 2007Article
- Comparative aspects of cerebral cortical development.The European journal of neuroscience · 2006Review
- The winged helix transcription factor Foxg1 facilitates retinal ganglion cell axon crossing of the ventral midline in the mouse.Development (Cambridge, England) · 2004Article
- R-cadherin is a Pax6-regulated, growth-promoting cue for pioneer axons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Early events in the formation of the thalamocortical tract remain poorly understood. Recent work has suggested that thalamocortical axons follow a path pioneered by transient thalamic afferents originating from the medial part of the ventral telencephalon. We studied the development of these transient afferents and the thalamocortical tract in mutant mice lacking transcription factors normally expressed in the dorsal thalamus or ventral telencephalon. Pax6 is expressed in the dorsal thalamus, but not in the medial part of the ventral telencephalon, and the thalamocortical tract fails to form in Pax6(-/-) embryos. We found that transient thalamic afferents from the ventral telencephalon do not form in Pax6(-/-) embryos; this may contribute to the failure of their thalamocortical development. The distribution of Pax6(-/-) cells in Pax6(-/-)<--> Pax6(+/+) chimeras supports conclusions drawn from forebrain marker gene expression that Pax6 is not required for the normal development of the medial part of the ventral telencephalon but is required in the dorsal thalamus. Failure of the transient afferent pathway to develop is therefore likely a cell nonautonomous defect reflecting primary defects in the thalamus. We then examined the formation of thalamic afferents and efferents in Foxg1(-/-) embryos, which lack recognizable ventral telencephalic structures. In these embryos thalamic efferents navigate correctly through the thalamus but fail to turn laterally into the telencephalon, whereas other axons are able to cross the diencephalic/telencephalic boundary. Our results support a role for the ventral telencephalon in guiding the early development of the thalamocortical tract and identify a new role for the transcription factor Pax6 in regulating the ability of the thalamus to attract ventral telencephalic afferents.
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Identifiers
12351726PMC6218002W1680734741What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.