ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Pathfinding errors of corticospinal axons in neural cell adhesion molecule-deficient mice.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 49 citations in OpenAlex.
- Protocadherin 19 regulates axon guidance in the developing Xenopus retinotectal pathway.Molecular brain · 2024Article
- Ventricular Netrin-1 deficiency leads to defective pyramidal decussation and mirror movement in mice.Cell death & disease · 2024Article
- Symmetry in levels of axon-axon homophilic adhesion establishes topography in the corpus callosum and development of connectivity between brain hemispheres.bioRxiv : the preprint server for biology · 2024Article
- Role of DSCAM in the Development of Neural Control of Movement and Locomotion.International journal of molecular sciences · 2021Review
- Abnormal Pyramidal Decussation and Bilateral Projection of the Corticospinal Tract Axons in Mice Lacking the Heparan Sulfate Endosulfatases, Sulf1 and Sulf2.Frontiers in molecular neuroscience · 2019Article
- One hand clapping: lateralization of motor control.Frontiers in neuroanatomy · 2015Review
- Sialic acids in the brain: gangliosides and polysialic acid in nervous system development, stability, disease, and regeneration.Physiological reviews · 2014Review
- Progression in multiple sclerosis is associated with low endogenous NCAM.Journal of neurochemistry · 2013Article
- Guidance of longitudinally projecting axons in the developing central nervous system.Frontiers in molecular neuroscience · 2012Article
- Podocalyxin is a novel polysialylated neural adhesion protein with multiple roles in neural development and synapse formation.PloS one · 2010Article
- Protogenin defines a transition stage during embryonic neurogenesis and prevents precocious neuronal differentiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- IgCAMs redundantly control axon navigation in Caenorhabditis elegans.Neural development · 2009Article
- Semaphorin-6A controls guidance of corticospinal tract axons at multiple choice points.Neural development · 2008Article
- Voltage-gated Na+ channels: potential for beta subunits as therapeutic targets.Expert opinion on therapeutic targets · 2008Article
- Dorsal turning of motor corticospinal axons at the pyramidal decussation requires plexin signaling.Neural development · 2008Article
- Voltage-gated Na+ channel beta1 subunit-mediated neurite outgrowth requires Fyn kinase and contributes to postnatal CNS development in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Differential gene expression and functional analysis implicate novel mechanisms in enteric nervous system precursor migration and neuritogenesis.Developmental biology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neural cell adhesion molecule (NCAM) is a cell recognition molecule of the Ig superfamily implicated in cell migration, myelination, and synaptic plasticity, as well as elongation, fasciculation, and pathfinding of axons. Here, we used NCAM-deficient mice to investigate the role of NCAM in the development of the corticospinal tract. We demonstrate severe hypoplasia of the corticospinal tract in adult NCAM mutants. Anterograde tracing of the tract of early postnatal NCAM mutants revealed pronounced pathfinding errors of corticospinal axons. At the pyramidal decussation of mutant mice, some corticospinal axons either stayed ventrally and extended laterally, or axons turned dorsally, but instead of growing to the contralateral dorsal column, a significant fraction of axons projected ipsilaterally. We also observed that corticospinal axons of NCAM mutants entered the pyramidal decussation significantly later than axons of wild-type littermates. Our observations thus demonstrate a critical role of NCAM for the formation of this major axon tract.
Indexed as
Identifiers
12351709PMC6757776W1523318924What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.