Evidence map›Paper›PMID 12350273›Full record

ArticleProceedings. Biological sciences2002

Parental modifiers, antisense transcripts and loss of imprinting.

Jon F Wilkins, David Haig

Open access · greenAbstract read
In one paragraph

Article in Proceedings. Biological sciences, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 34 citations in OpenAlex.

  1. Brinkmanship in intragenomic conflict.Proceedings. Biological sciences · 2025
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  2. Review
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  5. Review
  6. Article
  7. Review
  8. Review
  9. Specialists and generalists: the sexual ecology of the genome.Cold Spring Harbor perspectives in biology · 2014
    Review
  10. The maternal to zygotic transition in mammals.Molecular aspects of medicine · 2013
    Review
  11. Article
  12. Article
  13. Article
  14. Epigenetic asymmetry in the mammalian zygote and early embryo: relationship to lineage commitment?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2003
    Article
  15. A framework for detecting and characterizing genetic background-dependent imprinting effects.Mammalian genome : official journal of the International Mammalian Genome Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jon F WilkinsProgram in Biophysics, Harvard University, Cambridge, MA 02138, USA. jfwilkin@fas.harvard.edu
David Haig
Harvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The kinship theory of genomic imprinting has explained parent-specific gene expression as the outcome of an evolutionary conflict between the two alleles at a diploid locus of an offspring over how much to demand from parents. Previous models have predicted that maternally derived (madumnal) alleles will be silent at demand-enhancing loci, while paternally derived (padumnal) alleles will be silent at demand-suppressing loci, but these models have not considered the evolution of trans-acting modifiers that are expressed in parents and influence imprinted expression in offspring. We show that such modifiers will sometimes be selected to reactivate the silent padumnal allele at a demand-suppressing locus but will not be selected to reactivate the silent madumnal allele at a demand-enhancing locus. Therefore, imprinting of demand-suppressing loci is predicted to be less evolutionarily stable than imprinting of demand-enhancing loci.

Indexed as

Genomic ImprintingAllelesAnimalsBiological EvolutionDNA, AntisenseDNA MethylationFemaleGene SilencingMaleModels, GeneticMutationTranscription, GeneticDNA, Antisense

Identifiers

PMID12350273
PMCPMC1691092
OpenAlexW2142845337

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.